Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2219531..2219747 Replicon chromosome
Accession NZ_CP034005
Organism Staphylococcus aureus strain P1D7C1

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag EFD70_RS11045 Protein ID WP_001802298.1
Coordinates 2219643..2219747 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2219531..2219586 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD70_RS11025 2215737..2216402 - 666 WP_001024095.1 SDR family oxidoreductase -
EFD70_RS11030 2216554..2216874 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EFD70_RS11035 2216876..2217853 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
EFD70_RS11040 2218119..2219210 + 1092 WP_156668041.1 transcriptional regulator -
- 2219531..2219586 + 56 - - Antitoxin
EFD70_RS11045 2219643..2219747 - 105 WP_001802298.1 hypothetical protein Toxin
EFD70_RS14040 2220264..2220434 + 171 WP_001792292.1 transposase -
EFD70_RS11050 2220427..2220585 + 159 WP_001792784.1 hypothetical protein -
EFD70_RS11055 2221243..2222100 - 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
EFD70_RS11060 2222168..2222950 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T114898 WP_001802298.1 NZ_CP034005:c2219747-2219643 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T114898 NZ_CP034005:c2219747-2219643 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT114898 NZ_CP034005:2219531-2219586 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References