Detailed information of TA system TA114887

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1556782..1557361
• Replicon: chromosome
• Accession: NZ_CP034005
• Organism: Staphylococcus aureus strain P1D7C1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EFD70_RS07440
• Protein ID: WP_001025401.1
• Coordinates: 1557116..1557361 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1556782..1557147 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD70_RS07400	1553524..1554081	-	558	WP_000645042.1	DUF2815 family protein	-
EFD70_RS07405	1554108..1555274	-	1167	WP_000762527.1	DUF2800 domain-containing protein	-
EFD70_RS07410	1555271..1555633	-	363	WP_000985972.1	hypothetical protein	-
EFD70_RS07415	1555648..1555971	-	324	WP_000174998.1	hypothetical protein	-
EFD70_RS07420	1556050..1556211	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EFD70_RS07425	1556224..1556487	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EFD70_RS07430	1556512..1556727	-	216	WP_001097552.1	hypothetical protein	-
EFD70_RS07435	1556782..1557147	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EFD70_RS07440	1557116..1557361	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EFD70_RS07445	1557428..1557808	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EFD70_RS07450	1557795..1557992	-	198	WP_001148860.1	hypothetical protein	-
EFD70_RS07455	1558062..1558274	+	213	WP_000362644.1	hypothetical protein	-
EFD70_RS14025	1558315..1558464	-	150	WP_000771849.1	hypothetical protein	-
EFD70_RS07460	1558479..1558922	-	444	WP_000435357.1	hypothetical protein	-
EFD70_RS07465	1558970..1559182	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EFD70_RS07470	1559334..1560065	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EFD70_RS07475	1560135..1560317	+	183	WP_000705240.1	hypothetical protein	-
EFD70_RS07480	1560353..1560499	+	147	WP_001795334.1	hypothetical protein	-
EFD70_RS07485	1560496..1561110	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1514336..1580066	65730

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T114887 WP_001025401.1 NZ_CP034005:c1557361-1557116 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T114887 NZ_CP034005:c1557361-1557116 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT114887 NZ_CP034005:1556782-1557147 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin