Detailed information of TA system TA114869

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1556777..1557356
• Replicon: chromosome
• Accession: NZ_CP034002
• Organism: Staphylococcus aureus strain P1D8C1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EFD71_RS07440
• Protein ID: WP_001025401.1
• Coordinates: 1557111..1557356 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1556777..1557142 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD71_RS07400	1553519..1554076	-	558	WP_000645042.1	DUF2815 family protein	-
EFD71_RS07405	1554103..1555269	-	1167	WP_000762527.1	DUF2800 domain-containing protein	-
EFD71_RS07410	1555266..1555628	-	363	WP_000985972.1	hypothetical protein	-
EFD71_RS07415	1555643..1555966	-	324	WP_000174998.1	hypothetical protein	-
EFD71_RS07420	1556045..1556206	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EFD71_RS07425	1556219..1556482	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EFD71_RS07430	1556507..1556722	-	216	WP_001097552.1	hypothetical protein	-
EFD71_RS07435	1556777..1557142	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EFD71_RS07440	1557111..1557356	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EFD71_RS07445	1557423..1557803	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EFD71_RS07450	1557790..1557987	-	198	WP_001148860.1	hypothetical protein	-
EFD71_RS07455	1558057..1558269	+	213	WP_000362644.1	hypothetical protein	-
EFD71_RS14035	1558310..1558459	-	150	WP_000771849.1	hypothetical protein	-
EFD71_RS07460	1558474..1558917	-	444	WP_000435357.1	hypothetical protein	-
EFD71_RS07465	1558965..1559177	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EFD71_RS07470	1559329..1560060	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EFD71_RS07475	1560130..1560312	+	183	WP_000705240.1	hypothetical protein	-
EFD71_RS07480	1560348..1560494	+	147	WP_001795334.1	hypothetical protein	-
EFD71_RS07485	1560491..1561105	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp	1508987..1580061	71074

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T114869 WP_001025401.1 NZ_CP034002:c1557356-1557111 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T114869 NZ_CP034002:c1557356-1557111 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT114869 NZ_CP034002:1556777-1557142 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin