Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2525715..2526232 Replicon chromosome
Accession NZ_CP033987
Organism Staphylococcus aureus strain P2D1C1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag EFD76_RS12795 Protein ID WP_000113265.1
Coordinates 2525715..2525981 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EFD76_RS12800 Protein ID WP_000584499.1
Coordinates 2525981..2526232 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD76_RS12765 2521143..2521679 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EFD76_RS12770 2521913..2522737 - 825 WP_000572038.1 formate/nitrite transporter family protein -
EFD76_RS12775 2522954..2523136 - 183 WP_000230292.1 hypothetical protein -
EFD76_RS12780 2523220..2523687 - 468 WP_000153347.1 SRPBCC domain-containing protein -
EFD76_RS12785 2523873..2525420 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EFD76_RS12790 2525609..2525680 - 72 Protein_2432 hypothetical protein -
EFD76_RS12795 2525715..2525981 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
EFD76_RS12800 2525981..2526232 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EFD76_RS12805 2526397..2526498 - 102 Protein_2435 hypothetical protein -
EFD76_RS12810 2526505..2527104 - 600 WP_000162810.1 DsbA family protein -
EFD76_RS12815 2527123..2527485 - 363 WP_000819843.1 DUF4467 domain-containing protein -
EFD76_RS12820 2527740..2528990 + 1251 WP_156675479.1 FemA/FemB family glycyltransferase FmhA -
EFD76_RS12825 2529087..2529818 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EFD76_RS12830 2529815..2530534 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T114810 WP_000113265.1 NZ_CP033987:c2525981-2525715 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T114810 NZ_CP033987:c2525981-2525715 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT114810 WP_000584499.1 NZ_CP033987:c2526232-2525981 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT114810 NZ_CP033987:c2526232-2525981 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References