Detailed information of TA system TA114775

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2549606..2549790
• Replicon: chromosome
• Accession: NZ_CP033977
• Organism: Staphylococcus aureus strain P2D15C1

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: EFD78_RS12955
• Protein ID: WP_000482652.1
• Coordinates: 2549683..2549790 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2549606..2549666 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD78_RS12940	2545061..2545228	-	168	Protein_2459	hypothetical protein	-
EFD78_RS12945	2545459..2547192	-	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
EFD78_RS12950	2547217..2548980	-	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
-	2549606..2549666	+	61	-	-	Antitoxin
EFD78_RS12955	2549683..2549790	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
EFD78_RS12960	2549924..2550310	-	387	WP_000779360.1	flippase GtxA	-
EFD78_RS12965	2550578..2551720	+	1143	WP_001176863.1	glycerate kinase	-
EFD78_RS12970	2551780..2552439	+	660	WP_000831298.1	membrane protein	-
EFD78_RS12975	2552621..2553832	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
EFD78_RS12980	2553955..2554428	-	474	WP_156675480.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T114775 WP_000482652.1 NZ_CP033977:c2549790-2549683 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T114775 NZ_CP033977:c2549790-2549683 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT114775 NZ_CP033977:2549606-2549666 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin