Detailed information of TA system TA114761

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1603334..1603913
• Replicon: chromosome
• Accession: NZ_CP033977
• Organism: Staphylococcus aureus strain P2D15C1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EFD78_RS07865
• Protein ID: WP_001025401.1
• Coordinates: 1603668..1603913 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1603334..1603699 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD78_RS07825	1600076..1600633	-	558	WP_000645042.1	DUF2815 family protein	-
EFD78_RS07830	1600660..1601826	-	1167	WP_156675475.1	DUF2800 domain-containing protein	-
EFD78_RS07835	1601823..1602185	-	363	WP_000985972.1	hypothetical protein	-
EFD78_RS07840	1602200..1602523	-	324	WP_000174998.1	hypothetical protein	-
EFD78_RS07845	1602602..1602763	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EFD78_RS07850	1602776..1603039	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EFD78_RS07855	1603064..1603279	-	216	WP_001097552.1	hypothetical protein	-
EFD78_RS07860	1603334..1603699	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EFD78_RS07865	1603668..1603913	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EFD78_RS07870	1603980..1604360	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EFD78_RS07875	1604347..1604544	-	198	WP_001148860.1	hypothetical protein	-
EFD78_RS07880	1604614..1604826	+	213	WP_000362644.1	hypothetical protein	-
EFD78_RS14475	1604867..1605016	-	150	WP_000771849.1	hypothetical protein	-
EFD78_RS07885	1605031..1605474	-	444	WP_000435357.1	hypothetical protein	-
EFD78_RS07890	1605522..1605734	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EFD78_RS07895	1605886..1606617	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EFD78_RS07900	1606687..1606869	+	183	WP_000705240.1	hypothetical protein	-
EFD78_RS07905	1606905..1607051	+	147	WP_001795334.1	hypothetical protein	-
EFD78_RS07910	1607048..1607662	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1564264..1621745	57481

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T114761 WP_001025401.1 NZ_CP033977:c1603913-1603668 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T114761 NZ_CP033977:c1603913-1603668 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT114761 NZ_CP033977:1603334-1603699 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin