Detailed information of TA system TA114608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 223404..224056
• Replicon: chromosome
• Accession: NZ_CP033893
• Organism: Serratia liquefaciens strain FG3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EGO53_RS01035
• Protein ID: WP_142814507.1
• Coordinates: 223712..224056 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A515CQP0
• Locus tag: EGO53_RS01030
• Protein ID: WP_020828411.1
• Coordinates: 223404..223706 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO53_RS01010	218691..219599	+	909	WP_142814505.1	LysR family transcriptional regulator	-
EGO53_RS01015	219917..221071	+	1155	WP_142814506.1	MFS transporter	-
EGO53_RS01020	221061..221984	-	924	WP_046372747.1	LysR family transcriptional regulator	-
EGO53_RS01025	222111..223373	+	1263	WP_046372748.1	diaminopimelate decarboxylase	-
EGO53_RS01030	223404..223706	-	303	WP_020828411.1	helix-turn-helix transcriptional regulator	Antitoxin
EGO53_RS01035	223712..224056	-	345	WP_142814507.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGO53_RS01040	224196..225206	-	1011	WP_142814508.1	LacI family DNA-binding transcriptional regulator	-
EGO53_RS01045	225358..225813	+	456	WP_128865138.1	GNAT family N-acetyltransferase	-
EGO53_RS01050	225810..226829	-	1020	WP_020828407.1	HTH-type transcriptional regulator GalR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13491.61 Da
• Isoelectric Point: 10.8313

>T114608 WP_142814507.1 NZ_CP033893:c224056-223712 [Serratia liquefaciens]
MWQIVTVERFDSWFLSLNSDQQKSVLVGIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
ALLCGGDKTGNKRFYQQMLPIAIREFPHYLATQR

Nucleotide

• Length: 345 bp

>T114608 NZ_CP033893:c224056-223712 [Serratia liquefaciens]
ATGTGGCAGATCGTGACCGTCGAACGATTCGACAGCTGGTTTTTATCATTAAACAGCGATCAACAAAAAAGCGTGCTGGT
AGGAATATTCAAACTGCAGGAATTCGGCCCCTTGTTGGCGCGTCCTCATGCCGACACGCTGAATCACAAAAACCAAATAC
AGCATCTGAAAGAGTTACGTATTCAGCATCGCGGTCGGCCGTTTCGGATTTTCTTCGCCTTCGATCCGCAACGACAAGCG
GCCCTGCTTTGCGGTGGCGATAAAACCGGTAATAAACGCTTCTATCAACAAATGTTGCCGATCGCCATCAGAGAGTTTCC
ACATTACTTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11170.02 Da
• Isoelectric Point: 8.6182

>AT114608 WP_020828411.1 NZ_CP033893:c223706-223404 [Serratia liquefaciens]
MAKPLSDLIDRLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT114608 NZ_CP033893:c223706-223404 [Serratia liquefaciens]
ATGGCCAAACCCTTATCAGATCTGATCGACAGACTCGATCCCACCGTAGTTGAAGCTGCGCAACAGAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCAATGCTTCGGGAAGAACTGGCGGTGTCTCAGGTGGAACTGGCCAAGCGGCTTGGTATCA
GCCAACCTTCGGTCGCCAACCTGGAAAAACGCGGCAGCGAAATTAAACTCTCTTCACTCAAACGCTATATCGAAGCCATG
GGGGGAACGCTGTCGCTGGAAGTTCAGCTCCCGAACGGCCAGCATCGACGGATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A515CQP0