Detailed information of TA system TA114536

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1579965..1580272
• Replicon: chromosome
• Accession: NZ_CP033865
• Organism: Staphylococcus aureus strain FDAARGOS_504

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: EG363_RS08305
• Protein ID: WP_011447039.1
• Coordinates: 1580096..1580272 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1579965..1580104 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG363_RS08255	1575310..1575570	+	261	WP_001791826.1	hypothetical protein	-
EG363_RS08260	1575623..1575973	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
EG363_RS08265	1576656..1577105	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
EG363_RS08270	1577200..1577534	-	335	Protein_1544	SH3 domain-containing protein	-
EG363_RS08285	1578181..1578672	-	492	WP_000920042.1	staphylokinase	-
EG363_RS08290	1578863..1579618	-	756	WP_000861026.1	CHAP domain-containing protein	-
EG363_RS08295	1579630..1579884	-	255	WP_000611512.1	phage holin	-
EG363_RS08300	1579936..1580043	+	108	WP_031762631.1	hypothetical protein	-
-	1579965..1580104	+	140	NuclAT_0	-	Antitoxin
-	1579965..1580104	+	140	NuclAT_0	-	Antitoxin
-	1579965..1580104	+	140	NuclAT_0	-	Antitoxin
-	1579965..1580104	+	140	NuclAT_0	-	Antitoxin
EG363_RS08305	1580096..1580272	-	177	WP_011447039.1	putative holin-like toxin	Toxin
EG363_RS08310	1580475..1581230	-	756	WP_029729062.1	staphylococcal enterotoxin type P	-
EG363_RS08315	1581668..1582042	-	375	WP_000340977.1	hypothetical protein	-
EG363_RS08320	1582098..1582385	-	288	WP_001262621.1	hypothetical protein	-
EG363_RS08325	1582431..1582583	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / see / hlb / groEL	1575623..1629145	53522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T114536 WP_011447039.1 NZ_CP033865:c1580272-1580096 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T114536 NZ_CP033865:c1580272-1580096 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT114536 NZ_CP033865:1579965-1580104 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin