Detailed information of TA system TA114532

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1381986..1382166
• Replicon: chromosome
• Accession: NZ_CP033865
• Organism: Staphylococcus aureus strain FDAARGOS_504

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EG363_RS06960
• Protein ID: WP_001801861.1
• Coordinates: 1381986..1382081 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1382109..1382166 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG363_RS06925	1377130..1377756	+	627	WP_000669038.1	hypothetical protein	-
EG363_RS06930	1377797..1378141	+	345	WP_000627550.1	DUF3969 family protein	-
EG363_RS06935	1378239..1378811	+	573	WP_000414222.1	hypothetical protein	-
EG363_RS06940	1378960..1380327	-	1368	WP_078263561.1	FRG domain-containing protein	-
EG363_RS06945	1380327..1380896	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
EG363_RS06950	1381089..1381535	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
EG363_RS06960	1381986..1382081	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1382109..1382166	-	58	-	-	Antitoxin
EG363_RS06965	1382204..1382305	+	102	WP_001791232.1	hypothetical protein	-
EG363_RS06970	1382480..1382923	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
EG363_RS06975	1382923..1383366	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
EG363_RS06980	1383366..1383808	-	443	Protein_1330	DUF1433 domain-containing protein	-
EG363_RS06985	1384332..1386752	+	2421	WP_064135637.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T114532 WP_001801861.1 NZ_CP033865:1381986-1382081 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T114532 NZ_CP033865:1381986-1382081 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT114532 NZ_CP033865:c1382166-1382109 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin