Detailed information of TA system TA114508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3717878..3718099
• Replicon: chromosome
• Accession: NZ_CP033850
• Organism: Escherichia coli strain FDAARGOS_497

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A1D7PZ30
• Locus tag: EGY17_RS19915
• Protein ID: WP_022645587.1
• Coordinates: 3717878..3717985 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3718033..3718099 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY17_RS19890	3713722..3714804	+	1083	WP_022645584.1	peptide chain release factor 1	-
EGY17_RS19895	3714804..3715637	+	834	WP_022645585.1	peptide chain release factor N(5)-glutamine methyltransferase	-
EGY17_RS19900	3715634..3716026	+	393	WP_000200374.1	invasion regulator SirB2	-
EGY17_RS19905	3716030..3716839	+	810	WP_022645586.1	invasion regulator SirB1	-
EGY17_RS19910	3716875..3717729	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
EGY17_RS19915	3717878..3717985	-	108	WP_022645587.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3718033..3718099	+	67	NuclAT_31	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_31	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_31	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_31	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_33	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_33	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_33	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_33	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_35	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_35	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_35	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_35	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_37	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_37	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_37	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_37	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_39	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_39	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_39	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_39	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_41	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_41	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_41	-	Antitoxin
-	3718033..3718099	+	67	NuclAT_41	-	Antitoxin
-	3718035..3718092	+	58	NuclAT_44	-	-
-	3718035..3718092	+	58	NuclAT_44	-	-
-	3718035..3718092	+	58	NuclAT_44	-	-
-	3718035..3718092	+	58	NuclAT_44	-	-
EGY17_RS19920	3718413..3718520	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3718573..3718634	+	62	NuclAT_43	-	-
-	3718573..3718634	+	62	NuclAT_43	-	-
-	3718573..3718634	+	62	NuclAT_43	-	-
-	3718573..3718634	+	62	NuclAT_43	-	-
-	3718573..3718635	+	63	NuclAT_32	-	-
-	3718573..3718635	+	63	NuclAT_32	-	-
-	3718573..3718635	+	63	NuclAT_32	-	-
-	3718573..3718635	+	63	NuclAT_32	-	-
-	3718573..3718635	+	63	NuclAT_34	-	-
-	3718573..3718635	+	63	NuclAT_34	-	-
-	3718573..3718635	+	63	NuclAT_34	-	-
-	3718573..3718635	+	63	NuclAT_34	-	-
-	3718573..3718635	+	63	NuclAT_36	-	-
-	3718573..3718635	+	63	NuclAT_36	-	-
-	3718573..3718635	+	63	NuclAT_36	-	-
-	3718573..3718635	+	63	NuclAT_36	-	-
-	3718573..3718635	+	63	NuclAT_38	-	-
-	3718573..3718635	+	63	NuclAT_38	-	-
-	3718573..3718635	+	63	NuclAT_38	-	-
-	3718573..3718635	+	63	NuclAT_38	-	-
-	3718573..3718635	+	63	NuclAT_40	-	-
-	3718573..3718635	+	63	NuclAT_40	-	-
-	3718573..3718635	+	63	NuclAT_40	-	-
-	3718573..3718635	+	63	NuclAT_40	-	-
-	3718573..3718635	+	63	NuclAT_42	-	-
-	3718573..3718635	+	63	NuclAT_42	-	-
-	3718573..3718635	+	63	NuclAT_42	-	-
-	3718573..3718635	+	63	NuclAT_42	-	-
EGY17_RS19925	3718926..3720026	-	1101	WP_001301956.1	sodium-potassium/proton antiporter ChaA	-
EGY17_RS19930	3720296..3720526	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
EGY17_RS19935	3720684..3721379	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
EGY17_RS19940	3721423..3721776	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4029.82 Da
• Isoelectric Point: 11.4779

>T114508 WP_022645587.1 NZ_CP033850:c3717985-3717878 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAVIVSWWRNRK

Nucleotide

• Length: 108 bp

>T114508 NZ_CP033850:c3717985-3717878 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT114508 NZ_CP033850:3718033-3718099 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGGTTCTC

Structures

Toxin

• AlphaFold DB: A0A1D7PZ30

Antitoxin