Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4627196..4627856 Replicon chromosome
Accession NZ_CP033831
Organism Serratia sp. FDAARGOS_506

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EGY12_RS22435 Protein ID WP_123895425.1
Coordinates 4627503..4627856 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGY12_RS22430 Protein ID WP_123895424.1
Coordinates 4627196..4627498 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY12_RS22410 4622677..4623591 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
EGY12_RS22415 4623717..4624835 - 1119 WP_123895422.1 branched-chain amino acid ABC transporter substrate-binding protein -
EGY12_RS22425 4625567..4626775 - 1209 WP_123895423.1 aldose 1-epimerase family protein -
EGY12_RS22430 4627196..4627498 - 303 WP_123895424.1 XRE family transcriptional regulator Antitoxin
EGY12_RS22435 4627503..4627856 - 354 WP_123895425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGY12_RS22440 4628295..4629590 + 1296 WP_123895426.1 MFS transporter -
EGY12_RS22445 4629618..4630424 + 807 WP_123895427.1 substrate-binding domain-containing protein -
EGY12_RS22450 4630399..4631298 - 900 WP_123895428.1 LysR family transcriptional regulator -
EGY12_RS22455 4631401..4631766 - 366 WP_123895663.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(25-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13525.43 Da        Isoelectric Point: 9.0573

>T114431 WP_123895425.1 NZ_CP033831:c4627856-4627503 [Serratia sp. FDAARGOS_506]
VWEIKTTDAFDNWFSSLTDADRAGVLAALMVLREKRPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

>T114431 NZ_CP033831:c4627856-4627503 [Serratia sp. FDAARGOS_506]
GTGTGGGAAATTAAGACAACGGATGCGTTTGATAACTGGTTTAGCTCACTCACCGATGCCGATCGGGCCGGCGTGCTTGC
CGCATTGATGGTCCTGCGGGAAAAGAGGCCGGGGCTGCCCAGGCCCTATGCCGATACGGTTAAAGGTTCACGTTACAGCA
ATATGAAAGAGCTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGTATCGGCATT
GTGCTTTGTGCGGGCAATAAAGCCGGTAATGAAAAACGTTTTTACGATCGGATGATCCAGGCTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11045.88 Da        Isoelectric Point: 5.7316

>AT114431 WP_123895424.1 NZ_CP033831:c4627498-4627196 [Serratia sp. FDAARGOS_506]
MGRTLEQLIADEKPEVVANAQALAADIMLNIHLAELREKVQKTQVEMAQVLGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEVVL

Download         Length: 303 bp

>AT114431 NZ_CP033831:c4627498-4627196 [Serratia sp. FDAARGOS_506]
ATGGGCAGAACGTTGGAACAGCTTATTGCCGATGAAAAGCCCGAGGTCGTGGCCAACGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGCGAAAAAGTGCAGAAAACGCAGGTTGAAATGGCGCAGGTGCTGGGGATCC
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAGCTGTCTTCGCTAAAACGCTATGTTGAGGCTGCG
GGTGGCAAACTGCGCCTGGATGTTGAACTGCCGGACGGCTCTCACTACGAAGTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References