114419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 933277..934007 Replicon chromosome
Accession NZ_CP033831
Organism Serratia sp. FDAARGOS_506

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EGY12_RS04685 Protein ID WP_123892721.1
Coordinates 933277..933588 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGY12_RS04690 Protein ID WP_060424657.1
Coordinates 933585..934007 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY12_RS04655 928588..929313 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
EGY12_RS04660 929366..930799 + 1434 WP_123892718.1 RNA polymerase factor sigma-54 -
EGY12_RS04665 930823..931110 + 288 WP_004937038.1 ribosome hibernation promoting factor -
EGY12_RS04670 931266..931727 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
EGY12_RS04675 931857..932711 + 855 WP_123892719.1 RNase adapter RapZ -
EGY12_RS04680 932708..932980 + 273 WP_123892720.1 PTS phosphocarrier protein NPr -
EGY12_RS04685 933277..933588 + 312 WP_123892721.1 type II toxin-antitoxin system HigB family toxin Toxin
EGY12_RS04690 933585..934007 + 423 WP_060424657.1 helix-turn-helix domain-containing protein Antitoxin
EGY12_RS04695 934012..935928 - 1917 WP_123892722.1 BglG family transcription antiterminator -
EGY12_RS04700 935980..937194 - 1215 WP_123892723.1 lactonase family protein -
EGY12_RS04705 937405..938145 - 741 WP_123892724.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12308.18 Da        Isoelectric Point: 10.2571

>T114419 WP_123892721.1 NZ_CP033831:933277-933588 [Serratia sp. FDAARGOS_506]
MHIISREPFNNATKQYPNEAAALEAIYKTLRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSRAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T114419 NZ_CP033831:933277-933588 [Serratia sp. FDAARGOS_506]
ATGCATATCATTTCCAGGGAACCGTTTAATAACGCAACGAAGCAATACCCTAATGAAGCCGCTGCTCTCGAGGCCATTTA
TAAAACGTTGCGACGCGGCGAGTTTCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGTAACCACCTGCGGATTTTGTTCTTTGCCAGCTTTGAGACACAGAAAGTA
TTCATAAAGCACATTGTTAGCCGCGCCGAGTACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15673.97 Da        Isoelectric Point: 4.9590

>AT114419 WP_060424657.1 NZ_CP033831:933585-934007 [Serratia sp. FDAARGOS_506]
MITDAIKAADALLRAVPLLQGSGSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT114419 NZ_CP033831:933585-934007 [Serratia sp. FDAARGOS_506]
ATGATTACAGATGCCATTAAGGCCGCCGATGCGCTGCTGCGCGCCGTGCCCTTATTGCAGGGCAGCGGCTCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGATAACAGCGCCGAGTTTACCGCATTCAACCAGCGTATCGCCCAACTGCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGCAAAAAGTCGTTGGTCAA
CCAAATCCTGAGCGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAACGCTTCAATCTGCCCCCGGCTC
TCTTTCTGCCGGAAGCAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References