Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1305556..1306069 Replicon chromosome
Accession NZ_CP033822
Organism Streptococcus agalactiae strain FDAARGOS_512

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EGX82_RS06940 Protein ID WP_000481712.1
Coordinates 1305815..1306069 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EGX82_RS06935 Protein ID WP_000387490.1
Coordinates 1305556..1305822 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX82_RS06900 1301803..1303035 + 1233 WP_000338839.1 replication initiation factor domain-containing protein -
EGX82_RS06905 1303051..1303428 + 378 WP_000287185.1 hypothetical protein -
EGX82_RS06910 1303415..1303645 + 231 WP_001866982.1 helix-turn-helix domain-containing protein -
EGX82_RS06915 1303638..1303991 + 354 WP_000571928.1 helix-turn-helix domain-containing protein -
EGX82_RS06920 1304123..1304395 + 273 WP_000072643.1 hypothetical protein -
EGX82_RS06925 1304448..1304930 + 483 WP_000383283.1 antirestriction protein ArdA -
EGX82_RS06930 1304938..1305411 + 474 WP_000560386.1 hypothetical protein -
EGX82_RS06935 1305556..1305822 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EGX82_RS06940 1305815..1306069 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EGX82_RS06945 1306122..1307075 + 954 WP_000565541.1 conjugal transfer protein -
EGX82_RS06950 1307096..1307362 + 267 WP_001055037.1 hypothetical protein -
EGX82_RS06955 1307366..1307776 + 411 WP_000390749.1 conjugal transfer protein -
EGX82_RS06960 1307797..1310298 + 2502 WP_000239404.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1295602..1321119 25517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T114402 WP_000481712.1 NZ_CP033822:1305815-1306069 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T114402 NZ_CP033822:1305815-1306069 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT114402 WP_000387490.1 NZ_CP033822:1305556-1305822 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT114402 NZ_CP033822:1305556-1305822 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References