Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 789750..790263 Replicon chromosome
Accession NZ_CP033810
Organism Streptococcus sp. FDAARGOS_520

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EGX96_RS04085 Protein ID WP_000481712.1
Coordinates 789750..790004 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EGX96_RS04090 Protein ID WP_000387490.1
Coordinates 789997..790263 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX96_RS04060 786973..787775 - 803 Protein_769 IS5 family transposase -
EGX96_RS04065 787839..788015 - 177 Protein_770 conjugal transfer protein -
EGX96_RS04070 788036..788446 - 411 WP_000390747.1 conjugal transfer protein -
EGX96_RS04075 788457..788723 - 267 WP_001055037.1 hypothetical protein -
EGX96_RS04080 788744..789697 - 954 WP_000565540.1 conjugal transfer protein -
EGX96_RS04085 789750..790004 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EGX96_RS04090 789997..790263 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EGX96_RS04095 790408..790881 - 474 WP_000560386.1 hypothetical protein -
EGX96_RS04100 790889..791371 - 483 WP_000383283.1 antirestriction protein ArdA -
EGX96_RS04105 791424..791696 - 273 WP_000017154.1 hypothetical protein -
EGX96_RS04110 791831..792400 - 570 WP_000010056.1 hypothetical protein -
EGX96_RS04115 792403..793752 - 1350 WP_000491712.1 AAA family ATPase -
EGX96_RS04120 793949..794248 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
EGX96_RS04125 794232..794609 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 777011..818168 41157
- flank IS/Tn - - 787077..787361 284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T114380 WP_000481712.1 NZ_CP033810:c790004-789750 [Streptococcus sp. FDAARGOS_520]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T114380 NZ_CP033810:c790004-789750 [Streptococcus sp. FDAARGOS_520]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT114380 WP_000387490.1 NZ_CP033810:c790263-789997 [Streptococcus sp. FDAARGOS_520]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT114380 NZ_CP033810:c790263-789997 [Streptococcus sp. FDAARGOS_520]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References