Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 346599..347112 Replicon chromosome
Accession NZ_CP033809
Organism Streptococcus sp. FDAARGOS_521

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag EGX72_RS02010 Protein ID WP_000481712.1
Coordinates 346858..347112 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag EGX72_RS02005 Protein ID WP_000387490.1
Coordinates 346599..346865 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX72_RS01970 342253..342630 + 378 WP_000287183.1 hypothetical protein -
EGX72_RS01975 342614..342913 + 300 WP_123957705.1 helix-turn-helix domain-containing protein -
EGX72_RS01980 343110..344459 + 1350 WP_123957706.1 AAA family ATPase -
EGX72_RS01985 344462..345031 + 570 WP_000010056.1 hypothetical protein -
EGX72_RS01990 345166..345438 + 273 WP_000017154.1 hypothetical protein -
EGX72_RS01995 345491..345973 + 483 WP_000383283.1 antirestriction protein ArdA -
EGX72_RS02000 345981..346454 + 474 WP_000560386.1 hypothetical protein -
EGX72_RS02005 346599..346865 + 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EGX72_RS02010 346858..347112 + 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
EGX72_RS02015 347165..348118 + 954 WP_000565539.1 conjugal transfer protein -
EGX72_RS02020 348139..348405 + 267 WP_001055037.1 hypothetical protein -
EGX72_RS02025 348416..348826 + 411 WP_000390747.1 conjugal transfer protein -
EGX72_RS02030 348847..349023 + 177 Protein_346 conjugal transfer protein -
EGX72_RS02035 349087..349892 + 806 WP_088181596.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 349503..349892 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T114378 WP_000481712.1 NZ_CP033809:346858-347112 [Streptococcus sp. FDAARGOS_521]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T114378 NZ_CP033809:346858-347112 [Streptococcus sp. FDAARGOS_521]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT114378 WP_000387490.1 NZ_CP033809:346599-346865 [Streptococcus sp. FDAARGOS_521]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT114378 NZ_CP033809:346599-346865 [Streptococcus sp. FDAARGOS_521]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References