Detailed information of TA system TA114368

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1159113..1159373
• Replicon: chromosome
• Accession: NZ_CP033787
• Organism: Enterococcus faecalis strain FDAARGOS_528

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EGX75_RS05890
• Protein ID: WP_156194032.1
• Coordinates: 1159113..1159256 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1159189..1159373 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX75_RS05870	1154455..1156587	+	2133	WP_002359010.1	DNA mismatch repair endonuclease MutL	-
EGX75_RS05875	1156612..1157166	+	555	WP_002359011.1	septum formation protein Maf	-
EGX75_RS05880	1157299..1157736	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
EGX75_RS05885	1157911..1158882	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
EGX75_RS05890	1159113..1159256	+	144	WP_156194032.1	putative holin-like toxin	Toxin
-	1159189..1159373	-	185	-	-	Antitoxin
EGX75_RS05895	1159428..1160078	-	651	WP_002359015.1	beta-phosphoglucomutase	-
EGX75_RS05900	1160093..1162837	-	2745	WP_002404790.1	glycoside hydrolase family 65 protein	-
EGX75_RS05905	1163099..1163812	+	714	WP_002354877.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5327.50 Da
• Isoelectric Point: 10.8331

>T114368 WP_156194032.1 NZ_CP033787:1159113-1159256 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTISLIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T114368 NZ_CP033787:1159113-1159256 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTTCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT114368 NZ_CP033787:c1159373-1159189 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Structures

Antitoxin