Detailed information of TA system TA114348

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1081033..1081307
• Replicon: chromosome
• Accession: NZ_CP033787
• Organism: Enterococcus faecalis strain FDAARGOS_528

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EGX75_RS05500
• Protein ID: WP_077143780.1
• Coordinates: 1081167..1081307 (-)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1081033..1081234 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX75_RS05495	1080793..1080936	-	144	WP_002396786.1	putative holin-like toxin	-
-	1081033..1081234	+	202	-	-	Antitoxin
EGX75_RS05500	1081167..1081307	-	141	WP_077143780.1	putative holin-like toxin	Toxin
EGX75_RS05505	1081426..1081623	-	198	WP_002358966.1	putative holin-like toxin	-
EGX75_RS05510	1081809..1081931	-	123	WP_002404776.1	putative holin-like toxin	-
EGX75_RS05515	1082286..1083902	-	1617	WP_123839674.1	phosphatase PAP2/LCP family protein	-
EGX75_RS05530	1084364..1085659	+	1296	WP_002396787.1	AAA family ATPase	-
EGX75_RS05535	1085668..1086300	+	633	WP_002358972.1	RloB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5188.30 Da
• Isoelectric Point: 10.3265

>T114348 WP_077143780.1 NZ_CP033787:c1081307-1081167 [Enterococcus faecalis]
ISLKNTNKNIVYCTAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T114348 NZ_CP033787:c1081307-1081167 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT114348 NZ_CP033787:1081033-1081234 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin