Detailed information of TA system TA114342

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1080599..1080936
• Replicon: chromosome
• Accession: NZ_CP033787
• Organism: Enterococcus faecalis strain FDAARGOS_528

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: EGX75_RS05495
• Protein ID: WP_002396786.1
• Coordinates: 1080793..1080936 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1080599..1080861 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX75_RS05490	1075928..1080598	+	4671	WP_123839673.1	WxL domain-containing protein	-
-	1080599..1080861	+	263	-	-	Antitoxin
EGX75_RS05495	1080793..1080936	-	144	WP_002396786.1	putative holin-like toxin	Toxin
EGX75_RS05500	1081167..1081307	-	141	WP_077143780.1	putative holin-like toxin	-
EGX75_RS05505	1081426..1081623	-	198	WP_002358966.1	putative holin-like toxin	-
EGX75_RS05510	1081809..1081931	-	123	WP_002404776.1	putative holin-like toxin	-
EGX75_RS05515	1082286..1083902	-	1617	WP_123839674.1	phosphatase PAP2/LCP family protein	-
EGX75_RS05530	1084364..1085659	+	1296	WP_002396787.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T114342 WP_002396786.1 NZ_CP033787:c1080936-1080793 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T114342 NZ_CP033787:c1080936-1080793 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT114342 NZ_CP033787:1080599-1080861 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin