Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3614551..3615146 Replicon chromosome
Accession NZ_CP033771
Organism Pseudomonas aeruginosa strain FDAARGOS_532

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag EGY18_RS17290 Protein ID WP_003117425.1
Coordinates 3614868..3615146 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EGY18_RS17285 Protein ID WP_003099268.1
Coordinates 3614551..3614856 (-) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY18_RS17255 3609785..3610051 + 267 WP_016852153.1 hypothetical protein -
EGY18_RS17260 3610225..3611019 + 795 WP_023082695.1 helix-turn-helix domain-containing protein -
EGY18_RS17265 3610994..3612055 + 1062 Protein_3319 GNAT family N-acetyltransferase -
EGY18_RS17270 3612111..3613127 + 1017 WP_032728035.1 IS30-like element IS1394 family transposase -
EGY18_RS17275 3613102..3613635 + 534 WP_123906488.1 hypothetical protein -
EGY18_RS17280 3613647..3614174 - 528 WP_071535723.1 AAA family ATPase -
EGY18_RS17285 3614551..3614856 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
EGY18_RS17290 3614868..3615146 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGY18_RS17300 3615475..3617703 + 2229 WP_003099265.1 TonB-dependent receptor -
EGY18_RS17305 3617773..3618420 - 648 WP_003095021.1 carbonate dehydratase -
EGY18_RS17310 3618482..3619720 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3612111..3613127 1016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-92)

Antitoxin

(1-97)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T114300 WP_003117425.1 NZ_CP033771:c3615146-3614868 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T114300 NZ_CP033771:c3615146-3614868 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT114300 WP_003099268.1 NZ_CP033771:c3614856-3614551 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT114300 NZ_CP033771:c3614856-3614551 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCCGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5


Antitoxin

Source ID Structure

References