Detailed information of TA system TA114238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2577866..2578517
• Replicon: chromosome
• Accession: NZ_CP033754
• Organism: Acinetobacter baumannii strain FDAARGOS_540

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S3SZA7
• Locus tag: EGX84_RS13360
• Protein ID: WP_000269903.1
• Coordinates: 2578161..2578517 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EGX84_RS13355
• Protein ID: WP_001140619.1
• Coordinates: 2577866..2578168 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX84_RS13330	2573485..2574612	+	1128	WP_000655269.1	alkene reductase	-
EGX84_RS13335	2574696..2574926	-	231	WP_001087973.1	hypothetical protein	-
EGX84_RS13340	2575031..2575639	-	609	WP_000804053.1	TetR/AcrR family transcriptional regulator	-
EGX84_RS13345	2575783..2576691	+	909	Protein_2456	NADP-dependent oxidoreductase	-
EGX84_RS13350	2576743..2577675	-	933	WP_004739252.1	IS5-like element ISAba13 family transposase	-
EGX84_RS13355	2577866..2578168	-	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
EGX84_RS13360	2578161..2578517	-	357	WP_000269903.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGX84_RS13365	2579066..2580391	-	1326	WP_123785635.1	ISNCY family transposase	-
EGX84_RS13370	2580648..2580842	-	195	WP_004739051.1	hypothetical protein	-
EGX84_RS13375	2580957..2581175	+	219	WP_119689452.1	hypothetical protein	-
EGX84_RS13380	2581175..2582332	+	1158	WP_123785636.1	replication initiation factor domain-containing protein	-
EGX84_RS13385	2582335..2582631	+	297	WP_000983197.1	hypothetical protein	-
EGX84_RS13395	2583143..2583361	+	219	WP_001093107.1	phage coat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2564035..2598187	34152
	-	inside	IScluster/Tn	-	-	2576743..2590847	14104

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13486.45 Da
• Isoelectric Point: 7.1645

>T114238 WP_000269903.1 NZ_CP033754:c2578517-2578161 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T114238 NZ_CP033754:c2578517-2578161 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT114238 WP_001140619.1 NZ_CP033754:c2578168-2577866 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT114238 NZ_CP033754:c2578168-2577866 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: A0A836MG83