Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 545..1130 Replicon plasmid unnamed3
Accession NZ_CP033751
Organism Acinetobacter baumannii strain FDAARGOS_540

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag EGX84_RS00010 Protein ID WP_000897309.1
Coordinates 810..1130 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A009MRQ1
Locus tag EGX84_RS00005 Protein ID WP_032001914.1
Coordinates 545..817 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX84_RS00005 545..817 - 273 WP_032001914.1 helix-turn-helix domain-containing protein Antitoxin
EGX84_RS00010 810..1130 - 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX84_RS00015 1317..1514 - 198 WP_000476222.1 hypothetical protein -
EGX84_RS00020 1581..1808 - 228 WP_000921865.1 hypothetical protein -
EGX84_RS00025 1906..2121 - 216 WP_000071892.1 cold-shock protein -
EGX84_RS00030 2447..2878 - 432 WP_000390052.1 hypothetical protein -
EGX84_RS00035 2896..3162 - 267 WP_006581723.1 hypothetical protein -
EGX84_RS00040 3373..4809 + 1437 WP_059264791.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..7181 7181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T114235 WP_000897309.1 NZ_CP033751:c1130-810 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T114235 NZ_CP033751:c1130-810 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10088.61 Da        Isoelectric Point: 8.6582

>AT114235 WP_032001914.1 NZ_CP033751:c817-545 [Acinetobacter baumannii]
MDNNLLDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT114235 NZ_CP033751:c817-545 [Acinetobacter baumannii]
ATGGATAACAACTTATTAGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A009MRQ1

References