Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 937267..937961 Replicon chromosome
Accession NZ_CP033699
Organism Yersinia pestis strain FDAARGOS_601

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag EGX46_RS04965 Protein ID WP_002214787.1
Coordinates 937267..937563 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag EGX46_RS04970 Protein ID WP_002209924.1
Coordinates 937563..937961 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX46_RS04925 932380..932571 + 192 Protein_769 DUF4102 domain-containing protein -
EGX46_RS04935 932637..933419 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
EGX46_RS04940 933416..934438 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -
EGX46_RS04945 934495..935553 + 1059 WP_002220106.1 tyrosine-type recombinase/integrase -
EGX46_RS04950 935635..935820 - 186 WP_002209928.1 hypothetical protein -
EGX46_RS04955 936418..936678 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX46_RS04960 936741..937103 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
EGX46_RS04965 937267..937563 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
EGX46_RS04970 937563..937961 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EGX46_RS04975 938361..940652 - 2292 WP_002209923.1 toprim domain-containing protein -
EGX46_RS04980 940952..941278 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX46_RS24030 941271..941423 + 153 WP_002209921.1 hypothetical protein -
EGX46_RS04985 941437..941637 - 201 WP_002209920.1 AlpA family transcriptional regulator -
EGX46_RS04990 941819..942151 - 333 WP_002214791.1 hypothetical protein -
EGX46_RS04995 942157..942393 - 237 WP_002214792.1 hypothetical protein -
EGX46_RS05000 942406..942771 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T114057 WP_002214787.1 NZ_CP033699:937267-937563 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T114057 NZ_CP033699:937267-937563 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT114057 WP_002209924.1 NZ_CP033699:937563-937961 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT114057 NZ_CP033699:937563-937961 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References