Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2404987..2405681 Replicon chromosome
Accession NZ_CP033696
Organism Yersinia pestis strain FDAARGOS_602

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag EGX42_RS12405 Protein ID WP_002214787.1
Coordinates 2405385..2405681 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag EGX42_RS12400 Protein ID WP_002209924.1
Coordinates 2404987..2405385 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX42_RS12370 2400177..2400542 + 366 WP_002209919.1 hypothetical protein -
EGX42_RS12375 2400555..2400791 + 237 WP_002214792.1 hypothetical protein -
EGX42_RS12380 2400797..2401129 + 333 WP_002214791.1 hypothetical protein -
EGX42_RS12385 2401311..2401511 + 201 WP_002209920.1 AlpA family transcriptional regulator -
EGX42_RS23120 2401525..2401677 - 153 WP_002209921.1 hypothetical protein -
EGX42_RS12390 2401670..2401996 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX42_RS12395 2402296..2404587 + 2292 WP_002209923.1 toprim domain-containing protein -
EGX42_RS12400 2404987..2405385 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EGX42_RS12405 2405385..2405681 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
EGX42_RS12410 2405845..2406207 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
EGX42_RS12415 2406270..2406530 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX42_RS22920 2407128..2407322 + 195 WP_042659217.1 hypothetical protein -
EGX42_RS12425 2407378..2408592 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
EGX42_RS12435 2409025..2410542 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T114041 WP_002214787.1 NZ_CP033696:c2405681-2405385 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T114041 NZ_CP033696:c2405681-2405385 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT114041 WP_002209924.1 NZ_CP033696:c2405385-2404987 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT114041 NZ_CP033696:c2405385-2404987 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References