Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2076681..2077375 Replicon chromosome
Accession NZ_CP033690
Organism Yersinia pestis strain FDAARGOS_603

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag EGX74_RS10095 Protein ID WP_002214787.1
Coordinates 2076681..2076977 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag EGX74_RS10100 Protein ID WP_002209924.1
Coordinates 2076977..2077375 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX74_RS10065 2071803..2073320 + 1518 WP_002209930.1 lysine--tRNA ligase -
EGX74_RS10075 2073753..2074967 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
EGX74_RS10080 2075049..2075234 - 186 WP_002209928.1 hypothetical protein -
EGX74_RS10085 2075832..2076092 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX74_RS10090 2076155..2076517 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
EGX74_RS10095 2076681..2076977 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
EGX74_RS10100 2076977..2077375 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EGX74_RS10105 2077775..2080066 - 2292 WP_002209923.1 toprim domain-containing protein -
EGX74_RS10110 2080366..2080692 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX74_RS23955 2080685..2080837 + 153 WP_002209921.1 hypothetical protein -
EGX74_RS10115 2080851..2081051 - 201 WP_002209920.1 AlpA family transcriptional regulator -
EGX74_RS10120 2081233..2081565 - 333 WP_002214791.1 hypothetical protein -
EGX74_RS10125 2081571..2081807 - 237 WP_002214792.1 hypothetical protein -
EGX74_RS10130 2081820..2082185 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T114027 WP_002214787.1 NZ_CP033690:2076681-2076977 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T114027 NZ_CP033690:2076681-2076977 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT114027 WP_002209924.1 NZ_CP033690:2076977-2077375 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT114027 NZ_CP033690:2076977-2077375 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References