Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4281568..4282165 Replicon chromosome
Accession NZ_CP033631
Organism Klebsiella sp. P1CD1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DTA24_RS21280 Protein ID WP_012968756.1
Coordinates 4281848..4282165 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DTA24_RS21275 Protein ID WP_012542525.1
Coordinates 4281568..4281855 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTA24_RS21245 4277478..4277726 + 249 WP_008805539.1 DUF1158 domain-containing protein -
DTA24_RS21250 4277743..4278084 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
DTA24_RS21255 4278115..4279230 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
DTA24_RS21260 4279410..4279991 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
DTA24_RS21265 4279991..4280359 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
DTA24_RS21270 4280479..4281132 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
DTA24_RS21275 4281568..4281855 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
DTA24_RS21280 4281848..4282165 - 318 WP_012968756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DTA24_RS21285 4282350..4283393 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
DTA24_RS21295 4283923..4284789 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
DTA24_RS21300 4284898..4286325 + 1428 WP_123837057.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12124.41 Da        Isoelectric Point: 11.2767

>T113921 WP_012968756.1 NZ_CP033631:c4282165-4281848 [Klebsiella sp. P1CD1]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
IKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T113921 NZ_CP033631:c4282165-4281848 [Klebsiella sp. P1CD1]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
ATCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT113921 WP_012542525.1 NZ_CP033631:c4281855-4281568 [Klebsiella sp. P1CD1]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp

>AT113921 NZ_CP033631:c4281855-4281568 [Klebsiella sp. P1CD1]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References