Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1835523..1836301 Replicon chromosome
Accession NZ_CP033597
Organism Pasteurella multocida strain Q

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EER76_RS08500 Protein ID WP_156694365.1
Coordinates 1835523..1835846 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EER76_RS08505 Protein ID WP_005757699.1
Coordinates 1835975..1836301 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EER76_RS08475 1830840..1831526 + 687 WP_061406323.1 hypothetical protein -
EER76_RS08480 1831580..1833109 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
EER76_RS08485 1833218..1833835 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
EER76_RS08490 1833946..1834815 + 870 WP_061406325.1 VirK/YbjX family protein -
EER76_RS08495 1834889..1835365 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EER76_RS08500 1835523..1835846 + 324 WP_156694365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EER76_RS08505 1835975..1836301 + 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
EER76_RS08510 1836356..1837876 - 1521 WP_061406327.1 DUF560 domain-containing protein -
EER76_RS08515 1837935..1838525 - 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
EER76_RS08520 1838588..1839598 - 1011 WP_061406328.1 hypothetical protein -
EER76_RS08525 1839834..1840865 - 1032 WP_061406329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12795.57 Da        Isoelectric Point: 9.4691

>T113827 WP_156694365.1 NZ_CP033597:1835523-1835846 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPTSGLYSIRVNVK
YRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 324 bp

>T113827 NZ_CP033597:1835523-1835846 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGCG
ATTTGCGAAGTCAACCAGGTAATAAATTGGAAAAATTGGAGCCTACGAGTGGGCTATATTCTATCAGAGTGAATGTGAAA
TATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAGATT
ATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT113827 WP_005757699.1 NZ_CP033597:1835975-1836301 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT113827 NZ_CP033597:1835975-1836301 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCGAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References