Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6217910..6218607 Replicon chromosome
Accession NZ_CP033581
Organism Streptomyces sp. ADI95-16

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EES41_RS27820 Protein ID WP_123080791.1
Coordinates 6217910..6218272 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag EES41_RS27825 Protein ID WP_123080792.1
Coordinates 6218269..6218607 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EES41_RS27800 6212930..6213337 + 408 WP_123080787.1 peptide-methionine (R)-S-oxide reductase MsrB -
EES41_RS27805 6213384..6214346 - 963 WP_123080788.1 hypothetical protein -
EES41_RS27810 6214232..6215464 - 1233 WP_123080789.1 AAA family ATPase -
EES41_RS27815 6215763..6217823 + 2061 WP_123080790.1 phospholipase C, phosphocholine-specific -
EES41_RS27820 6217910..6218272 + 363 WP_123080791.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EES41_RS27825 6218269..6218607 + 339 WP_123080792.1 XRE family transcriptional regulator Antitoxin
EES41_RS41615 6218710..6218877 + 168 WP_164495959.1 hypothetical protein -
EES41_RS27835 6219006..6219812 - 807 WP_123082734.1 hypothetical protein -
EES41_RS27840 6219896..6220396 - 501 WP_123080793.1 hypothetical protein -
EES41_RS27845 6220472..6221329 + 858 WP_123080794.1 LysR family transcriptional regulator -
EES41_RS27850 6221319..6222479 + 1161 WP_123080795.1 aminopeptidase P family protein -
EES41_RS27855 6222499..6222888 - 390 WP_174261846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(28-101)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.15 Da        Isoelectric Point: 4.4458

>T113825 WP_123080791.1 NZ_CP033581:6217910-6218272 [Streptomyces sp. ADI95-16]
VILVAEVATWFETLTESDWDSAEQVEDAVEALAMFGPTLGRPLVDRIKGSDQHHMKELRPGSSGGSEIRILFAFDPIRRA
VLLVAGDKAGNWQGWYEANIPLAEKRYQAHIAELETREYE

Download         Length: 363 bp

>T113825 NZ_CP033581:6217910-6218272 [Streptomyces sp. ADI95-16]
GTGATCCTCGTCGCTGAGGTCGCGACGTGGTTCGAGACGCTGACCGAGTCGGACTGGGACAGCGCCGAACAGGTGGAAGA
CGCGGTGGAAGCCCTCGCGATGTTCGGGCCGACGCTCGGACGGCCGCTGGTGGACCGCATCAAGGGGTCGGACCAGCACC
ACATGAAGGAGCTGAGACCCGGCTCCTCGGGTGGCAGCGAGATCAGGATCCTGTTCGCGTTCGACCCGATCCGTCGTGCC
GTGCTGCTCGTGGCGGGGGACAAGGCGGGAAACTGGCAGGGCTGGTACGAAGCGAACATCCCGCTCGCGGAGAAGCGCTA
CCAGGCCCATATCGCCGAGCTGGAGACCAGGGAGTACGAATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12311.91 Da        Isoelectric Point: 6.4079

>AT113825 WP_123080792.1 NZ_CP033581:6218269-6218607 [Streptomyces sp. ADI95-16]
MSAVGWEEVKRQVYERRAAAGLPVRSAAEKRAAMDRLVAEVRAYRLAEIRQQQALTQKDVAETMGVSAPRVSAIENGETD
RTEVATLRSYVEALGGRLRVVADFGDAEYTVA

Download         Length: 339 bp

>AT113825 NZ_CP033581:6218269-6218607 [Streptomyces sp. ADI95-16]
ATGAGCGCCGTCGGCTGGGAGGAAGTCAAGCGCCAGGTGTATGAGCGCCGCGCGGCGGCCGGACTGCCGGTGCGGTCGGC
CGCCGAGAAGCGGGCCGCCATGGACCGGCTGGTCGCCGAGGTCCGGGCGTACCGGCTCGCGGAGATCCGGCAGCAGCAGG
CGCTGACGCAGAAGGACGTGGCCGAGACGATGGGCGTCTCCGCCCCTCGGGTGTCGGCGATCGAGAACGGTGAGACCGAC
CGCACCGAGGTGGCCACCCTGCGCTCGTACGTCGAGGCCCTCGGAGGGCGGCTCCGGGTCGTGGCGGACTTCGGCGACGC
CGAGTACACGGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References