Detailed information of TA system TA113757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3498809..3499461
• Replicon: chromosome
• Accession: NZ_CP033504
• Organism: Serratia sp. LS-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EDY99_RS16720
• Protein ID: WP_089195112.1
• Coordinates: 3498809..3499153 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: EDY99_RS16725
• Protein ID: WP_038878665.1
• Coordinates: 3499159..3499461 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EDY99_RS16705	3494602..3495156	+	555	WP_046687732.1	hypothetical protein	-
EDY99_RS16710	3495128..3497410	-	2283	WP_123061937.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
EDY99_RS16715	3497631..3498650	+	1020	WP_033652132.1	HTH-type transcriptional regulator GalR	-
EDY99_RS16720	3498809..3499153	+	345	WP_089195112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EDY99_RS16725	3499159..3499461	+	303	WP_038878665.1	helix-turn-helix transcriptional regulator	Antitoxin
EDY99_RS16730	3499489..3500751	-	1263	WP_033644838.1	diaminopimelate decarboxylase	-
EDY99_RS16735	3500885..3501808	+	924	WP_046687734.1	LysR family transcriptional regulator	-
EDY99_RS16740	3501836..3502744	-	909	WP_033644836.1	LysR family transcriptional regulator	-
EDY99_RS16745	3502853..3503737	+	885	WP_046687735.1	MBL fold metallo-hydrolase	-
EDY99_RS16750	3503806..3504453	+	648	WP_033644834.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13353.38 Da
• Isoelectric Point: 10.9964

>T113757 WP_089195112.1 NZ_CP033504:3498809-3499153 [Serratia sp. LS-1]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLRELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T113757 NZ_CP033504:3498809-3499153 [Serratia sp. LS-1]
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGACGCGGCCC
GGCAGTTGAGGGAGTTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT113757 WP_038878665.1 NZ_CP033504:3499159-3499461 [Serratia sp. LS-1]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT113757 NZ_CP033504:3499159-3499461 [Serratia sp. LS-1]
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7