Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2743776..2744436 Replicon chromosome
Accession NZ_CP033504
Organism Serratia sp. LS-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EDY99_RS13180 Protein ID WP_089194950.1
Coordinates 2744083..2744436 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag EDY99_RS13175 Protein ID WP_016927038.1
Coordinates 2743776..2744078 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDY99_RS13155 2739379..2740293 - 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -
EDY99_RS13160 2740418..2741536 - 1119 WP_123061820.1 branched-chain amino acid ABC transporter substrate-binding protein -
EDY99_RS13170 2742142..2743350 - 1209 WP_123061821.1 aldose 1-epimerase family protein -
EDY99_RS13175 2743776..2744078 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
EDY99_RS13180 2744083..2744436 - 354 WP_089194950.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EDY99_RS13185 2744875..2746170 + 1296 WP_123061822.1 MFS transporter -
EDY99_RS13190 2746197..2747003 + 807 WP_123061823.1 substrate-binding domain-containing protein -
EDY99_RS13195 2746978..2747877 - 900 WP_033643758.1 LysR family transcriptional regulator -
EDY99_RS13200 2747980..2748345 - 366 WP_033643759.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13532.47 Da        Isoelectric Point: 9.0587

>T113756 WP_089194950.1 NZ_CP033504:c2744436-2744083 [Serratia sp. LS-1]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T113756 NZ_CP033504:c2744436-2744083 [Serratia sp. LS-1]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCGCTTAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGGGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT113756 WP_016927038.1 NZ_CP033504:c2744078-2743776 [Serratia sp. LS-1]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT113756 NZ_CP033504:c2744078-2743776 [Serratia sp. LS-1]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATCGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References