Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2694923..2695543 Replicon chromosome
Accession NZ_CP033431
Organism Burkholderia gladioli strain Burkholderia gladioli Co14

Toxin (Protein)


Gene name higB Uniprot ID A0A3G3LFY7
Locus tag EDD84_RS31235 Protein ID WP_036037496.1
Coordinates 2694923..2695201 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3G3LHC5
Locus tag EDD84_RS31240 Protein ID WP_036037498.1
Coordinates 2695220..2695543 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDD84_RS31210 2689976..2690578 + 603 WP_013690210.1 TetR/AcrR family transcriptional regulator -
EDD84_RS31215 2690759..2691871 + 1113 WP_036037490.1 helix-turn-helix transcriptional regulator -
EDD84_RS31220 2692030..2692752 + 723 WP_036037491.1 fumarylacetoacetate hydrolase family protein -
EDD84_RS31225 2693017..2693886 + 870 WP_036037493.1 CPBP family intramembrane metalloprotease -
EDD84_RS31230 2694012..2694680 - 669 WP_013690206.1 MarC family protein -
EDD84_RS31235 2694923..2695201 + 279 WP_036037496.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EDD84_RS31240 2695220..2695543 + 324 WP_036037498.1 HigA family addiction module antidote protein Antitoxin
EDD84_RS31245 2695651..2696736 + 1086 WP_036037500.1 ionic transporter y4hA -
EDD84_RS31250 2696779..2697735 - 957 WP_025100402.1 LysR family transcriptional regulator -
EDD84_RS31255 2698129..2699307 + 1179 WP_123038113.1 HPP family protein -
EDD84_RS31260 2699415..2699828 + 414 WP_013690200.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10429.06 Da        Isoelectric Point: 9.9309

>T113702 WP_036037496.1 NZ_CP033431:2694923-2695201 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWRAVAQVARRKLAMLDAAQALRDLVVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T113702 NZ_CP033431:2694923-2695201 [Burkholderia gladioli]
ATGATTCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGCGTGCCGTGGCACA
AGTGGCCCGGCGCAAGCTGGCCATGCTCGATGCGGCCCAGGCACTGCGCGACCTGGTCGTGCCGCCCGGCAACCAGCTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTCTGTTTCGTCTGGAGCAGC
AGGGGCCCCGAGCTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11860.70 Da        Isoelectric Point: 7.2024

>AT113702 WP_036037498.1 NZ_CP033431:2695220-2695543 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPAGAAA

Download         Length: 324 bp

>AT113702 NZ_CP033431:2695220-2695543 [Burkholderia gladioli]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCTGGCGAAATCCTGCGCGAGGAGTTCCTGGT
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCCCCGCCGGCGCGGCGGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3LFY7

Antitoxin

Source ID Structure
AlphaFold DB A0A3G3LHC5

References