Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 633934..634436 Replicon chromosome
Accession NZ_CP033401
Organism Escherichia coli strain WCHEC020031

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EDM51_RS03825 Protein ID WP_000767829.1
Coordinates 634182..634436 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EDM51_RS03820 Protein ID WP_001259255.1
Coordinates 633934..634185 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EDM51_RS03795 629111..630178 - 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EDM51_RS03800 630178..631248 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
EDM51_RS03805 631245..632549 - 1305 WP_001317939.1 histidinol dehydrogenase -
EDM51_RS03810 632555..633454 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
EDM51_RS03815 633600..633650 - 51 WP_001364200.1 his operon leader peptide -
EDM51_RS03820 633934..634185 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EDM51_RS03825 634182..634436 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EDM51_RS03830 634519..635343 + 825 WP_000754758.1 SDR family oxidoreductase -
EDM51_RS03835 635389..636318 + 930 WP_000803351.1 LysR family transcriptional regulator -
EDM51_RS03840 636533..636595 + 63 WP_010723108.1 membrane protein YoeI -
EDM51_RS03845 636585..637943 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EDM51_RS03850 638122..639180 + 1059 WP_000492346.1 transport protein YeeE -
EDM51_RS03855 639194..639421 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T113637 WP_000767829.1 NZ_CP033401:634182-634436 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T113637 NZ_CP033401:634182-634436 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT113637 WP_001259255.1 NZ_CP033401:633934-634185 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT113637 NZ_CP033401:633934-634185 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References