Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2314..2965 Replicon plasmid pCFSAN076215
Accession NZ_CP033339
Organism Salmonella enterica subsp. enterica serovar Anatum strain CFSAN076215

Toxin (Protein)


Gene name higB Uniprot ID A0A5H6R623
Locus tag EAE34_RS23370 Protein ID WP_000271342.1
Coordinates 2314..2658 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2H4YPR7
Locus tag EAE34_RS23375 Protein ID WP_000166615.1
Coordinates 2651..2965 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE34_RS23365 958..2166 - 1209 WP_060634139.1 IncI1-type conjugal transfer protein TrbA -
EAE34_RS23370 2314..2658 + 345 WP_000271342.1 hypothetical protein Toxin
EAE34_RS23375 2651..2965 + 315 WP_000166615.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EAE34_RS23380 3133..3291 + 159 WP_079821826.1 Hok/Gef family protein -
EAE34_RS23385 3877..4326 + 450 WP_060634140.1 hypothetical protein -
EAE34_RS23390 4712..5359 - 648 WP_164708728.1 plasmid IncI1-type surface exclusion protein ExcA -
EAE34_RS23395 5439..6841 - 1403 Protein_7 DotA/TraY family protein -
EAE34_RS23400 6880..7671 - 792 Protein_8 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..104123 104123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 14758.04 Da        Isoelectric Point: 12.8568

>T113523 WP_000271342.1 NZ_CP033339:2314-2658 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 345 bp

>T113523 NZ_CP033339:2314-2658 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 13476.30 Da        Isoelectric Point: 12.8170

>AT113523 WP_000166615.1 NZ_CP033339:2651-2965 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 315 bp

>AT113523 NZ_CP033339:2651-2965 [Salmonella enterica subsp. enterica serovar Anatum]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6R623

Antitoxin

Source ID Structure
AlphaFold DB A0A2H4YPR7

References