Detailed information of TA system TA113478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3920..4505
• Replicon: plasmid pAba7835a
• Accession: NZ_CP033244
• Organism: Acinetobacter baumannii strain 7835

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: Aba7835_RS19430
• Protein ID: WP_063558593.1
• Coordinates: 4185..4505 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Aba7835_RS19425
• Protein ID: WP_063558592.1
• Coordinates: 3920..4192 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba7835_RS20130	1..576	+	576	WP_001096616.1	helix-turn-helix domain-containing protein	-
Aba7835_RS20060	596..739	+	144	WP_001125244.1	hypothetical protein	-
Aba7835_RS19415	1366..2391	-	1026	WP_010326927.1	IS30 family transposase	-
Aba7835_RS19420	2412..2723	+	312	WP_063558590.1	hypothetical protein	-
Aba7835_RS19425	3920..4192	-	273	WP_063558592.1	helix-turn-helix domain-containing protein	Antitoxin
Aba7835_RS19430	4185..4505	-	321	WP_063558593.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Aba7835_RS19435	4692..4889	-	198	WP_034583955.1	hypothetical protein	-
Aba7835_RS19440	4956..5183	-	228	WP_004745640.1	hypothetical protein	-
Aba7835_RS19445	5281..5496	-	216	WP_000071892.1	cold-shock protein	-
Aba7835_RS20065	5827..6003	-	177	WP_162885653.1	hypothetical protein	-
Aba7835_RS19450	6000..6371	-	372	WP_000504220.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..8536	8536
	-	flank	IS/Tn	-	-	1366..2391	1025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (17-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12139.90 Da
• Isoelectric Point: 6.9790

>T113478 WP_063558593.1 NZ_CP033244:c4505-4185 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYSQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T113478 NZ_CP033244:c4505-4185 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATAGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10121.55 Da
• Isoelectric Point: 7.2045

>AT113478 WP_063558592.1 NZ_CP033244:c4192-3920 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPNLI

Nucleotide

• Length: 273 bp

>AT113478 NZ_CP033244:c4192-3920 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATTAAAGAAGCTGGGGCTATCAAACGTAATGAGATAAAGGCCAG
TCGAGTCACAGAGCTTGAGTTACCGGACATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCAGAGTTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTACAGAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTCTAGATGCTCATCCAAATTTAATTTAA