Detailed information of TA system TA113372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4825731..4826320
• Replicon: chromosome
• Accession: NZ_CP033193
• Organism: Xanthomonas oryzae pv. oryzae strain JW11089

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A8E2YMU3
• Locus tag: EBA19_RS24195
• Protein ID: WP_011260747.1
• Coordinates: 4826039..4826320 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EBA19_RS24190
• Protein ID: WP_133265134.1
• Coordinates: 4825731..4826021 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA19_RS24150	4821006..4821482	-	477	WP_011260741.1	DUF4123 domain-containing protein	-
EBA19_RS24155	4821485..4821919	-	435	WP_011260742.1	PAAR domain-containing protein	-
EBA19_RS24160	4822057..4822281	-	225	WP_044751358.1	hypothetical protein	-
EBA19_RS24170	4822617..4822949	+	333	WP_011260743.1	hypothetical protein	-
EBA19_RS24180	4823399..4824793	-	1395	WP_011260745.1	nucleoside hydrolase	-
EBA19_RS24190	4825731..4826021	-	291	WP_133265134.1	HigA family addiction module antidote protein	Antitoxin
EBA19_RS24195	4826039..4826320	-	282	WP_011260747.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA19_RS24200	4826415..4828673	-	2259	WP_041182333.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11070.83 Da
• Isoelectric Point: 10.2139

>T113372 WP_011260747.1 NZ_CP033193:c4826320-4826039 [Xanthomonas oryzae pv. oryzae]
MIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQQRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T113372 NZ_CP033193:c4826320-4826039 [Xanthomonas oryzae pv. oryzae]
ATGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCAGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10419.13 Da
• Isoelectric Point: 10.0802

>AT113372 WP_133265134.1 NZ_CP033193:c4826021-4825731 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLKPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT113372 NZ_CP033193:c4826021-4825731 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCAAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA