Detailed information of TA system TA113305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4310071..4310723
• Replicon: chromosome
• Accession: NZ_CP033162
• Organism: Serratia sp. P2ACOL2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EBA31_RS20830
• Protein ID: WP_122080103.1
• Coordinates: 4310071..4310415 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A515CQP0
• Locus tag: EBA31_RS20835
• Protein ID: WP_020828411.1
• Coordinates: 4310421..4310723 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBA31_RS20815	4307298..4308317	+	1020	WP_020828407.1	HTH-type transcriptional regulator GalR	-
EBA31_RS20820	4308314..4308769	-	456	WP_122080102.1	GNAT family N-acetyltransferase	-
EBA31_RS20825	4308921..4309931	+	1011	WP_116691841.1	LacI family DNA-binding transcriptional regulator	-
EBA31_RS20830	4310071..4310415	+	345	WP_122080103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EBA31_RS20835	4310421..4310723	+	303	WP_020828411.1	helix-turn-helix transcriptional regulator	Antitoxin
EBA31_RS20840	4310754..4312016	-	1263	WP_122080104.1	diaminopimelate decarboxylase	-
EBA31_RS20845	4312143..4313066	+	924	WP_046372747.1	LysR family transcriptional regulator	-
EBA31_RS20850	4313056..4314210	-	1155	WP_122080105.1	MFS transporter	-
EBA31_RS20855	4314528..4315436	-	909	WP_020828415.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13509.63 Da
• Isoelectric Point: 10.8313

>T113305 WP_122080103.1 NZ_CP033162:4310071-4310415 [Serratia sp. P2ACOL2]
MWQIVTVERFDSWFLSLNSDQQKSVLVGIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
VLLCGGDKTGNKRFYQQMLPIAIREFSHYLATQR

Nucleotide

• Length: 345 bp

>T113305 NZ_CP033162:4310071-4310415 [Serratia sp. P2ACOL2]
ATGTGGCAGATCGTGACCGTCGAACGATTCGACAGCTGGTTTTTATCATTAAACAGCGATCAACAAAAAAGCGTGCTGGT
AGGAATATTCAAACTGCAGGAATTCGGCCCCTTGTTGGCGCGTCCTCATGCCGACACGCTGAATCACAAAAACCAAATAC
AGCATCTGAAAGAGTTACGTATTCAGCATCGCGGTCGGCCGTTTCGGATTTTCTTCGCCTTTGATCCGCAACGACAAGCG
GTCCTGCTTTGCGGTGGCGATAAAACCGGTAATAAACGCTTCTATCAACAAATGTTGCCGATCGCCATCAGAGAGTTTTC
ACATTACTTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11170.02 Da
• Isoelectric Point: 8.6182

>AT113305 WP_020828411.1 NZ_CP033162:4310421-4310723 [Serratia sp. P2ACOL2]
MAKPLSDLIDRLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT113305 NZ_CP033162:4310421-4310723 [Serratia sp. P2ACOL2]
ATGGCCAAACCCTTATCAGATCTGATCGACAGACTCGATCCCACCGTAGTTGAAGCTGCGCAACAGAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCAATGCTTCGGGAAGAACTGGCGGTGTCTCAGGTGGAACTGGCCAAGCGGCTTGGTATCA
GCCAACCTTCGGTCGCCAACCTGGAAAAACGCGGCAGCGAAATTAAACTCTCTTCACTCAAACGCTATATCGAAGCCATG
GGGGGAACGCTGTCGCTGGAAGTTCAGCTCCCGAACGGCCAGCATCGACGGATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A515CQP0