Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 214245..214843 Replicon chromosome
Accession NZ_CP033144
Organism Vibrio owensii strain V180403

Toxin (Protein)


Gene name higB Uniprot ID A0A7Z7VLH5
Locus tag D0856_RS01005 Protein ID WP_054103799.1
Coordinates 214520..214843 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7Z7VJV6
Locus tag D0856_RS01000 Protein ID WP_054103798.1
Coordinates 214245..214523 (-) Length 93 a.a.

Genomic Context

D0856_RS00985D0856_RS00990D0856_RS00995D0856_RS01010D0856_RS01015D0856_RS01020D0856_RS01025D0856_RS01030D0856_RS01035D0856_RS01000D0856_RS01005D0856_RS01040
Location: 211207..213027 (1821 bp)
Type: Others
Protein ID: WP_122067047.1
Location: 213037..213597 (561 bp)
Type: Others
Protein ID: WP_122067048.1
Location: 213584..214219 (636 bp)
Type: Others
Protein ID: WP_029627967.1
Location: 215024..215305 (282 bp)
Type: Others
Protein ID: WP_000433889.1
Location: 215302..215928 (627 bp)
Type: Others
Protein ID: WP_000667170.1
Location: 215912..216808 (897 bp)
Type: Others
Protein ID: WP_086597854.1
Location: 216811..218100 (1290 bp)
Type: Others
Protein ID: WP_086597841.1
Location: 218175..218747 (573 bp)
Type: Others
Protein ID: WP_001944091.1
Location: 218744..219130 (387 bp)
Type: Others
Protein ID: WP_023584042.1
Location: 214245..214523 (279 bp)
Type: Antitoxin
Protein ID: WP_054103798.1
Location: 214520..214843 (324 bp)
Type: Toxin
Protein ID: WP_054103799.1
Location: 219171..219677 (507 bp)
Type: Others
Protein ID: WP_023584043.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D0856_RS00985211207..213027+1821WP_122067047.1conjugative transfer system coupling protein TraD-
D0856_RS00990213037..213597+561WP_122067048.1conjugative transfer protein-
D0856_RS00995213584..214219+636WP_029627967.1DUF4400 domain-containing protein-
D0856_RS01000214245..214523-279WP_054103798.1helix-turn-helix domain-containing proteinAntitoxin
D0856_RS01005214520..214843-324WP_054103799.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D0856_RS01010215024..215305+282WP_000433889.1type IV conjugative transfer system protein TraL-
D0856_RS01015215302..215928+627WP_000667170.1hypothetical protein-
D0856_RS01020215912..216808+897WP_086597854.1type-F conjugative transfer system secretin TraK-
D0856_RS01025216811..218100+1290WP_086597841.1TraB/VirB10 family protein-
D0856_RS01030218175..218747+573WP_001944091.1type IV conjugative transfer system lipoprotein TraV-
D0856_RS01035218744..219130+387WP_023584042.1hypothetical protein-
D0856_RS01040219171..219677-507WP_023584043.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12295.35 Da        Isoelectric Point: 9.7658

>T113246 WP_054103799.1 NZ_CP033144:c214843-214520 [Vibrio owensii]
MSWKIDFYDGVEEQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGKHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

>T113246 NZ_CP033144:c214843-214520 [Vibrio owensii]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGAGCAGATCCTCGATATGCCTCCAAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAAGCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTTAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10503.05 Da        Isoelectric Point: 9.9393

>AT113246 WP_054103798.1 NZ_CP033144:c214523-214245 [Vibrio owensii]
MSLQKLKQRALANADVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp

>AT113246 NZ_CP033144:c214523-214245 [Vibrio owensii]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGATGTTAAGAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGACCAATTGCTTACCATGAGAACAAAGGCAGGACTTACTCAAGAACAAGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGTAATGCCAATCCAAGTTGGTCAACTCTTCTAAAATATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7Z7VLH5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7Z7VJV6

References