Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 8541..9192 | Replicon | plasmid pOXA58_010062 |
| Accession | NZ_CP033131 | ||
| Organism | Acinetobacter wuhouensis strain WCHAW010062 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N9BC17 |
| Locus tag | CDG68_RS02645 | Protein ID | WP_004967307.1 |
| Coordinates | 8836..9192 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CDG68_RS02640 | Protein ID | WP_001140620.1 |
| Coordinates | 8541..8843 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDG68_RS02605 | 3559..4116 | + | 558 | WP_005146114.1 | TetR/AcrR family transcriptional regulator | - |
| CDG68_RS02610 | 4154..4621 | + | 468 | WP_087554503.1 | DUF1643 domain-containing protein | - |
| CDG68_RS02615 | 4740..5108 | - | 369 | Protein_6 | IS1-like element ISAba3 family transposase | - |
| CDG68_RS02620 | 5189..6031 | + | 843 | WP_002002480.1 | carbapenem-hydrolyzing class D beta-lactamase OXA-58 | - |
| CDG68_RS02625 | 6122..6874 | + | 753 | Protein_8 | IS1-like element ISAba3 family transposase | - |
| CDG68_RS02630 | 7002..7829 | + | 828 | WP_000073658.1 | AraC family transcriptional regulator | - |
| CDG68_RS02635 | 7879..8484 | + | 606 | WP_000447788.1 | LysE family translocator | - |
| CDG68_RS02640 | 8541..8843 | - | 303 | WP_001140620.1 | XRE family transcriptional regulator | Antitoxin |
| CDG68_RS02645 | 8836..9192 | - | 357 | WP_004967307.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CDG68_RS02655 | 9413..10249 | - | 837 | WP_000480968.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| CDG68_RS02660 | 10249..11052 | - | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| CDG68_RS02665 | 11161..12381 | - | 1221 | WP_087554590.1 | IS256 family transposase | - |
| CDG68_RS02670 | 12450..13382 | - | 933 | WP_122071884.1 | IS5-like element IS17 family transposase | - |
| CDG68_RS02675 | 13432..13644 | - | 213 | Protein_17 | phosphoglucosamine mutase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaOXA-58 / aph(6)-Id / aph(3'')-Ib / sul2 / catB3 / ant(2'')-Ia / aadA24 / qacE / sul1 / blaPER-1 | - | 1..59191 | 59191 | |
| - | inside | IScluster/Tn | blaOXA-58 / aph(6)-Id / aph(3'')-Ib / sul2 | - | 1094..20197 | 19103 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13601.62 Da Isoelectric Point: 6.4648
>T113225 WP_004967307.1 NZ_CP033131:c9192-8836 [Acinetobacter wuhouensis]
MWIVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGSKKRFYKDMLDIADEQYQLHLTTLGDKSNG
MWIVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGSKKRFYKDMLDIADEQYQLHLTTLGDKSNG
Download Length: 357 bp
>T113225 NZ_CP033131:c9192-8836 [Acinetobacter wuhouensis]
ATGTGGATAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGACGAATCAACACAAGAGAAGGTTCTGGC
TGCCCTAGTTGTTCTACAGCAGCAAGGACCAAGTTTAGGCCGCCCTTTAGTAGATACTGTCTATGACTCTAAATTTACCA
ACATGAAAGAGCTTCGTGTTCAACATCGAGGTAAACCACTGAGAGCTTTCTTCGCATTTGATCCTTTACGACAGGCTATT
GTTCTATGTATTGCTGATAAAGGCAGTAAAAAGCGTTTTTATAAAGACATGCTGGATATTGCAGATGAACAATACCAACT
TCATCTCACCACCCTAGGAGATAAATCTAATGGCTAA
ATGTGGATAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGACGAATCAACACAAGAGAAGGTTCTGGC
TGCCCTAGTTGTTCTACAGCAGCAAGGACCAAGTTTAGGCCGCCCTTTAGTAGATACTGTCTATGACTCTAAATTTACCA
ACATGAAAGAGCTTCGTGTTCAACATCGAGGTAAACCACTGAGAGCTTTCTTCGCATTTGATCCTTTACGACAGGCTATT
GTTCTATGTATTGCTGATAAAGGCAGTAAAAAGCGTTTTTATAAAGACATGCTGGATATTGCAGATGAACAATACCAACT
TCATCTCACCACCCTAGGAGATAAATCTAATGGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11227.02 Da Isoelectric Point: 6.4759
>AT113225 WP_001140620.1 NZ_CP033131:c8843-8541 [Acinetobacter wuhouensis]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT113225 NZ_CP033131:c8843-8541 [Acinetobacter wuhouensis]
ATGGCTAAGACTCTGCAAGAATTGTTAGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATGGCAGATGAATT
ACTGCTAGAAAATCAGCTTCATCTTATTCGTGAAGAACTTGAAATCTCTCAAAAGGAACTTGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAGGCAATG
GGCGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA
ATGGCTAAGACTCTGCAAGAATTGTTAGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATGGCAGATGAATT
ACTGCTAGAAAATCAGCTTCATCTTATTCGTGAAGAACTTGAAATCTCTCAAAAGGAACTTGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAGGCAATG
GGCGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|