Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2548548..2548732 Replicon chromosome
Accession NZ_CP033114
Organism Staphylococcus aureus strain ST20130945

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAST45_RS12640 Protein ID WP_000482647.1
Coordinates 2548625..2548732 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2548548..2548608 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST45_RS12625 2544058..2544225 - 168 Protein_2439 hypothetical protein -
SAST45_RS12630 2544456..2546189 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
SAST45_RS12635 2546214..2547977 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2548548..2548608 + 61 - - Antitoxin
SAST45_RS12640 2548625..2548732 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAST45_RS12645 2548866..2549252 - 387 WP_000779351.1 flippase GtxA -
SAST45_RS12650 2549520..2550662 + 1143 WP_001176855.1 glycerate kinase -
SAST45_RS12655 2550722..2551381 + 660 WP_000831298.1 membrane protein -
SAST45_RS12660 2551563..2552774 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
SAST45_RS12665 2552897..2553370 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T113220 WP_000482647.1 NZ_CP033114:c2548732-2548625 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T113220 NZ_CP033114:c2548732-2548625 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT113220 NZ_CP033114:2548548-2548608 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References