Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2523246..2523763 Replicon chromosome
Accession NZ_CP033114
Organism Staphylococcus aureus strain ST20130945

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag SAST45_RS12505 Protein ID WP_000251928.1
Coordinates 2523246..2523512 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag SAST45_RS12510 Protein ID WP_000584497.1
Coordinates 2523512..2523763 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST45_RS12480 2518454..2518990 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
SAST45_RS12485 2519458..2520282 - 825 WP_000594640.1 formate/nitrite transporter family protein -
SAST45_RS12490 2520485..2520667 - 183 WP_000079140.1 hypothetical protein -
SAST45_RS12495 2520753..2521220 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAST45_RS12500 2521406..2522953 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAST45_RS12505 2523246..2523512 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
SAST45_RS12510 2523512..2523763 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAST45_RS12515 2523927..2524027 - 101 Protein_2417 hypothetical protein -
SAST45_RS12520 2524034..2524633 - 600 WP_000162804.1 DsbA family protein -
SAST45_RS12525 2524652..2525014 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAST45_RS12530 2525269..2526519 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
SAST45_RS12535 2526616..2527347 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
SAST45_RS12540 2527344..2528063 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T113219 WP_000251928.1 NZ_CP033114:c2523512-2523246 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T113219 NZ_CP033114:c2523512-2523246 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT113219 WP_000584497.1 NZ_CP033114:c2523763-2523512 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT113219 NZ_CP033114:c2523763-2523512 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References