Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2092799..2093222 Replicon chromosome
Accession NZ_CP033114
Organism Staphylococcus aureus strain ST20130945

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag SAST45_RS10210 Protein ID WP_001065091.1
Coordinates 2092971..2093222 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag SAST45_RS10205 Protein ID WP_000028422.1
Coordinates 2092799..2092981 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST45_RS10160 2088185..2089846 - 1662 WP_000625088.1 terminase large subunit -
SAST45_RS10165 2089843..2090187 - 345 WP_000402904.1 hypothetical protein -
SAST45_RS10170 2090317..2090616 - 300 WP_000988336.1 HNH endonuclease -
SAST45_RS10175 2090848..2091264 - 417 WP_000590122.1 hypothetical protein -
SAST45_RS10180 2091292..2091492 - 201 WP_000265043.1 DUF1514 family protein -
SAST45_RS10185 2091492..2091641 - 150 WP_000595265.1 transcriptional activator RinB -
SAST45_RS10190 2091638..2092024 - 387 WP_000592207.1 hypothetical protein -
SAST45_RS10195 2092021..2092227 - 207 WP_000195803.1 DUF1381 domain-containing protein -
SAST45_RS10200 2092264..2092806 - 543 WP_000185659.1 dUTP pyrophosphatase -
SAST45_RS10205 2092799..2092981 - 183 WP_000028422.1 hypothetical protein Antitoxin
SAST45_RS10210 2092971..2093222 - 252 WP_001065091.1 DUF1024 family protein Toxin
SAST45_RS14135 2093215..2093388 - 174 WP_001793974.1 hypothetical protein -
SAST45_RS10215 2093394..2093636 - 243 WP_000131366.1 hypothetical protein -
SAST45_RS10220 2093640..2094008 - 369 WP_000101274.1 hypothetical protein -
SAST45_RS10225 2094021..2094330 - 310 Protein_1972 RusA family crossover junction endodeoxyribonuclease -
SAST45_RS10230 2094339..2094557 - 219 WP_000338531.1 hypothetical protein -
SAST45_RS10235 2094564..2095448 - 885 WP_000148316.1 DnaD domain protein -
SAST45_RS10240 2095478..2095948 - 471 WP_000934764.1 single-stranded DNA-binding protein -
SAST45_RS10245 2095949..2096566 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
SAST45_RS10250 2096647..2097567 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL 2059356..2136075 76719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T113214 WP_001065091.1 NZ_CP033114:c2093222-2092971 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T113214 NZ_CP033114:c2093222-2092971 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT113214 WP_000028422.1 NZ_CP033114:c2092981-2092799 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT113214 NZ_CP033114:c2092981-2092799 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References