Detailed information of TA system TA113212

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2069488..2069787
• Replicon: chromosome
• Accession: NZ_CP033114
• Organism: Staphylococcus aureus strain ST20130945

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAST45_RS10060
• Protein ID: WP_011447039.1
• Coordinates: 2069611..2069787 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2069488..2069543 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST45_RS10020	2064818..2065078	+	261	WP_001791826.1	hypothetical protein	-
SAST45_RS10025	2065131..2065481	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAST45_RS10030	2066167..2066616	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAST45_RS10035	2066711..2067046	-	336	Protein_1933	SH3 domain-containing protein	-
SAST45_RS10040	2067696..2068187	-	492	WP_000919350.1	staphylokinase	-
SAST45_RS10045	2068378..2069133	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAST45_RS10050	2069145..2069399	-	255	WP_000611512.1	phage holin	-
SAST45_RS10055	2069451..2069558	+	108	WP_001791821.1	hypothetical protein	-
-	2069480..2069619	+	140	NuclAT_0	-	-
-	2069480..2069619	+	140	NuclAT_0	-	-
-	2069480..2069619	+	140	NuclAT_0	-	-
-	2069480..2069619	+	140	NuclAT_0	-	-
-	2069488..2069543	+	56	-	-	Antitoxin
SAST45_RS10060	2069611..2069787	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAST45_RS10065	2069896..2070669	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
SAST45_RS10070	2071090..2071464	-	375	WP_000340977.1	hypothetical protein	-
SAST45_RS10075	2071520..2071807	-	288	WP_001040259.1	hypothetical protein	-
SAST45_RS10080	2071854..2072006	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL	2059356..2136075	76719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T113212 WP_011447039.1 NZ_CP033114:c2069787-2069611 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T113212 NZ_CP033114:c2069787-2069611 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT113212 NZ_CP033114:2069488-2069543 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin