Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1898730..1898910 Replicon chromosome
Accession NZ_CP033114
Organism Staphylococcus aureus strain ST20130945

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag SAST45_RS09015 Protein ID WP_001801861.1
Coordinates 1898730..1898825 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1898853..1898910 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST45_RS08985 1893874..1894500 + 627 WP_000669038.1 hypothetical protein -
SAST45_RS08990 1894541..1894885 + 345 WP_000627550.1 DUF3969 family protein -
SAST45_RS08995 1894983..1895555 + 573 WP_000414222.1 hypothetical protein -
SAST45_RS09000 1895704..1897071 - 1368 WP_001093574.1 FRG domain-containing protein -
SAST45_RS09005 1897071..1897640 - 570 WP_000125075.1 ImmA/IrrE family metallo-endopeptidase -
SAST45_RS09010 1897833..1898279 - 447 WP_000747804.1 DUF1433 domain-containing protein -
SAST45_RS09015 1898730..1898825 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1898853..1898910 - 58 - - Antitoxin
SAST45_RS09020 1898948..1899049 + 102 WP_001791232.1 hypothetical protein -
SAST45_RS09025 1899224..1899667 - 444 WP_001037039.1 DUF1433 domain-containing protein -
SAST45_RS09030 1899667..1900110 - 444 WP_000731421.1 DUF1433 domain-containing protein -
SAST45_RS09035 1900110..1900552 - 443 Protein_1771 DUF1433 domain-containing protein -
SAST45_RS09040 1901077..1903497 + 2421 WP_000182553.1 polysaccharide lyase 8 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hysA 1887891..1934973 47082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T113208 WP_001801861.1 NZ_CP033114:1898730-1898825 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T113208 NZ_CP033114:1898730-1898825 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT113208 NZ_CP033114:c1898910-1898853 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References