Detailed information of TA system TA113207

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1008484..1008733
• Replicon: chromosome
• Accession: NZ_CP033114
• Organism: Staphylococcus aureus strain ST20130945

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: SAST45_RS04765
• Protein ID: WP_000623369.1
• Coordinates: 1008484..1008591 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1008586..1008733 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST45_RS04740	1005157..1005726	-	570	WP_000287265.1	competence protein ComK	-
SAST45_RS04745	1005936..1006154	+	219	WP_000876825.1	IDEAL domain-containing protein	-
SAST45_RS04750	1006235..1007221	-	987	WP_000668820.1	lipoate--protein ligase	-
SAST45_RS04755	1007420..1007596	+	177	WP_000214898.1	YkvS family protein	-
SAST45_RS04760	1007611..1008213	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
SAST45_RS04765	1008484..1008591	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1008586..1008733	-	148	-	-	Antitoxin
SAST45_RS04770	1009130..1009231	+	102	WP_001790623.1	hypothetical protein	-
SAST45_RS04775	1009241..1009513	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
SAST45_RS04780	1009557..1011521	+	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
SAST45_RS04785	1011524..1011844	+	321	WP_000873929.1	YxeA family protein	-
SAST45_RS04790	1011841..1012482	+	642	WP_000571191.1	ABC transporter ATP-binding protein	-
SAST45_RS04795	1012570..1012860	-	291	WP_001791476.1	hypothetical protein	-
SAST45_RS04800	1013201..1013488	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T113207 WP_000623369.1 NZ_CP033114:1008484-1008591 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T113207 NZ_CP033114:1008484-1008591 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT113207 NZ_CP033114:c1008733-1008586 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin