Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2590387..2590571 Replicon chromosome
Accession NZ_CP033112
Organism Staphylococcus aureus strain ST20130944

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAST44_RS12970 Protein ID WP_000482647.1
Coordinates 2590464..2590571 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2590387..2590447 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST44_RS12955 2585897..2586064 - 168 Protein_2508 hypothetical protein -
SAST44_RS12960 2586295..2588028 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
SAST44_RS12965 2588053..2589816 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2590387..2590447 + 61 - - Antitoxin
SAST44_RS12970 2590464..2590571 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAST44_RS12975 2590705..2591091 - 387 WP_000779351.1 flippase GtxA -
SAST44_RS12980 2591359..2592501 + 1143 WP_001176855.1 glycerate kinase -
SAST44_RS12985 2592561..2593220 + 660 WP_000831298.1 membrane protein -
SAST44_RS12990 2593402..2594613 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
SAST44_RS12995 2594736..2595209 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T113204 WP_000482647.1 NZ_CP033112:c2590571-2590464 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T113204 NZ_CP033112:c2590571-2590464 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT113204 NZ_CP033112:2590387-2590447 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References