Detailed information of TA system TA113195

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2111318..2111625
• Replicon: chromosome
• Accession: NZ_CP033112
• Organism: Staphylococcus aureus strain ST20130944

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAST44_RS10395
• Protein ID: WP_011447039.1
• Coordinates: 2111449..2111625 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2111318..2111457 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST44_RS10355	2106656..2106916	+	261	WP_001791826.1	hypothetical protein	-
SAST44_RS10360	2106969..2107319	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAST44_RS10365	2108005..2108454	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAST44_RS10370	2108549..2108884	-	336	Protein_2002	SH3 domain-containing protein	-
SAST44_RS10375	2109534..2110025	-	492	WP_000919350.1	staphylokinase	-
SAST44_RS10380	2110216..2110971	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAST44_RS10385	2110983..2111237	-	255	WP_000611512.1	phage holin	-
SAST44_RS10390	2111289..2111396	+	108	WP_001791821.1	hypothetical protein	-
-	2111318..2111457	+	140	NuclAT_1	-	Antitoxin
-	2111318..2111457	+	140	NuclAT_1	-	Antitoxin
-	2111318..2111457	+	140	NuclAT_1	-	Antitoxin
-	2111318..2111457	+	140	NuclAT_1	-	Antitoxin
SAST44_RS10395	2111449..2111625	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAST44_RS10400	2111734..2112507	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
SAST44_RS10405	2112928..2113302	-	375	WP_000340977.1	hypothetical protein	-
SAST44_RS10410	2113358..2113645	-	288	WP_001040259.1	hypothetical protein	-
SAST44_RS10415	2113692..2113844	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / hlb / tsst-1 / groEL	2106969..2174933	67964

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T113195 WP_011447039.1 NZ_CP033112:c2111625-2111449 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T113195 NZ_CP033112:c2111625-2111449 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT113195 NZ_CP033112:2111318-2111457 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin