Detailed information of TA system TA113192

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1940568..1940748
• Replicon: chromosome
• Accession: NZ_CP033112
• Organism: Staphylococcus aureus strain ST20130944

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAST44_RS09350
• Protein ID: WP_001801861.1
• Coordinates: 1940568..1940663 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1940691..1940748 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST44_RS09320	1935712..1936338	+	627	WP_000669038.1	hypothetical protein	-
SAST44_RS09325	1936379..1936723	+	345	WP_000627550.1	DUF3969 family protein	-
SAST44_RS09330	1936821..1937393	+	573	WP_000414222.1	hypothetical protein	-
SAST44_RS09335	1937542..1938909	-	1368	WP_001093574.1	FRG domain-containing protein	-
SAST44_RS09340	1938909..1939478	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
SAST44_RS09345	1939671..1940117	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
SAST44_RS09350	1940568..1940663	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1940691..1940748	-	58	-	-	Antitoxin
SAST44_RS09355	1940786..1940887	+	102	WP_001791232.1	hypothetical protein	-
SAST44_RS09360	1941062..1941505	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
SAST44_RS09365	1941505..1941948	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
SAST44_RS09370	1941948..1942390	-	443	Protein_1840	DUF1433 domain-containing protein	-
SAST44_RS09375	1942915..1945335	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hysA	1929730..1976811	47081

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T113192 WP_001801861.1 NZ_CP033112:1940568-1940663 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T113192 NZ_CP033112:1940568-1940663 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT113192 NZ_CP033112:c1940748-1940691 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin