Detailed information of TA system TA113189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1572992..1573299
• Replicon: chromosome
• Accession: NZ_CP033112
• Organism: Staphylococcus aureus strain ST20130944

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAST44_RS07435
• Protein ID: WP_011447039.1
• Coordinates: 1573123..1573299 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1572992..1573131 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST44_RS07400	1568123..1569031	-	909	WP_000476878.1	DUF1672 domain-containing protein	-
SAST44_RS07405	1569089..1569994	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
SAST44_RS14455	1570084..1570299	-	216	WP_170267452.1	hypothetical protein	-
SAST44_RS07415	1570676..1571512	-	837	WP_155716901.1	hypothetical protein	-
SAST44_RS07420	1571890..1572645	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAST44_RS07425	1572657..1572911	-	255	WP_000611512.1	phage holin	-
SAST44_RS07430	1572963..1573070	+	108	WP_001791821.1	hypothetical protein	-
-	1572992..1573131	+	140	NuclAT_0	-	Antitoxin
-	1572992..1573131	+	140	NuclAT_0	-	Antitoxin
-	1572992..1573131	+	140	NuclAT_0	-	Antitoxin
-	1572992..1573131	+	140	NuclAT_0	-	Antitoxin
SAST44_RS07435	1573123..1573299	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAST44_RS07440	1573408..1574181	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
SAST44_RS07445	1574602..1574976	-	375	WP_000340977.1	hypothetical protein	-
SAST44_RS07450	1575032..1575319	-	288	WP_001040259.1	hypothetical protein	-
SAST44_RS07455	1575366..1575518	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	ebp / sea	1500609..1604288	103679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T113189 WP_011447039.1 NZ_CP033112:c1573299-1573123 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T113189 NZ_CP033112:c1573299-1573123 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT113189 NZ_CP033112:1572992-1573131 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin