Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1149282..1150072 Replicon chromosome
Accession NZ_CP033104
Organism Pseudomonas sp. LTGT-11-2Z

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3G2HLC0
Locus tag D8767_RS05215 Protein ID WP_016713503.1
Coordinates 1149282..1149749 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0P7D0H8
Locus tag D8767_RS05220 Protein ID WP_016713504.1
Coordinates 1149746..1150072 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8767_RS05195 1144472..1146001 + 1530 WP_016713500.1 efflux transporter outer membrane subunit -
D8767_RS05200 1145998..1148175 + 2178 WP_016713501.1 FUSC family protein -
D8767_RS05205 1148165..1148365 + 201 WP_009685040.1 DUF1656 domain-containing protein -
D8767_RS05210 1148376..1149236 + 861 WP_121757793.1 HlyD family secretion protein -
D8767_RS05215 1149282..1149749 - 468 WP_016713503.1 type II toxin-antitoxin system YhaV family toxin Toxin
D8767_RS05220 1149746..1150072 - 327 WP_016713504.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
D8767_RS05225 1150166..1150612 - 447 WP_016713505.1 universal stress protein -
D8767_RS05230 1150883..1151788 + 906 WP_016713506.1 LysR family transcriptional regulator -
D8767_RS05235 1151905..1153446 + 1542 WP_016713507.1 MFS transporter -
D8767_RS05240 1153475..1154536 + 1062 WP_016713508.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18037.56 Da        Isoelectric Point: 10.0504

>T113160 WP_016713503.1 NZ_CP033104:c1149749-1149282 [Pseudomonas sp. LTGT-11-2Z]
MSDASRKPLVIHGWTVIAHPLFLAKLEALSAQVQAQMHKDPTGYTRRNAYKRLAAIKRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESSDDAYKVFQKMLHTGHPPDDWEQLLREAAAE

Download         Length: 468 bp

>T113160 NZ_CP033104:c1149749-1149282 [Pseudomonas sp. LTGT-11-2Z]
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTAATTGCCCACCCGCTGTTCCTGGCCAAACTGGA
GGCACTCAGCGCTCAAGTGCAGGCTCAGATGCACAAGGACCCAACGGGTTACACGCGCAGAAATGCCTATAAAAGGCTGG
CGGCCATCAAGCGACTGGCCTTCGATGTAATCCCTCAAGACCCGACCAAACCTGAGTACCGGCAGGGGGCCACACTGGGT
GGTGACCACAAGCACTGGTTCAGGGCAAAGTTCTTCCAGCAGTACCGGTTGTTCTTCCGCTATCACACCCCCAGCAGGAT
CATTGTGCTGGCCTGGGTCAATGACGAGTCGAGCAAGCGGGCCTACGAAAGTAGCGACGATGCTTACAAGGTCTTTCAGA
AGATGCTGCATACCGGCCACCCGCCGGACGATTGGGAGCAGCTACTGCGAGAAGCTGCAGCCGAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12007.46 Da        Isoelectric Point: 4.3118

>AT113160 WP_016713504.1 NZ_CP033104:c1150072-1149746 [Pseudomonas sp. LTGT-11-2Z]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQSLSADDE

Download         Length: 327 bp

>AT113160 NZ_CP033104:c1150072-1149746 [Pseudomonas sp. LTGT-11-2Z]
ATGGCAACCACTCTCGACGTCGAGTCCACACTGACCGATCGCTATCAGACCACTGTTCCCGAAACAGTACGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCTGACGGTGAGGTGATACTCACCCGTGCAGAAGCAACCG
AGAGCGATCCAGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCCACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGACCTCATCGCGCGTCTCGACAAGCTTGTCGGCGACGCAGAGGTCGACCTGGATCAATCTCTGTCGGCGGATGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2HLC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7D0H8

References