Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3745268..3745995 Replicon chromosome
Accession NZ_CP033102
Organism Enterobacter hormaechei strain L51

Toxin (Protein)


Gene name higB Uniprot ID A0A9E6WR45
Locus tag D8768_RS18275 Protein ID WP_045623285.1
Coordinates 3745268..3745579 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D8768_RS18280 Protein ID WP_045623284.1
Coordinates 3745576..3745995 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8768_RS18250 3741058..3741837 - 780 WP_139153954.1 acetolactate decarboxylase -
D8768_RS18255 3741943..3742839 + 897 WP_157508251.1 LysR family transcriptional regulator -
D8768_RS18260 3743066..3743278 - 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
D8768_RS18265 3743982..3744436 + 455 Protein_3580 hypothetical protein -
D8768_RS18270 3744637..3745047 + 411 WP_023299534.1 ASCH domain-containing protein -
D8768_RS18275 3745268..3745579 + 312 WP_045623285.1 type II toxin-antitoxin system HigB family toxin Toxin
D8768_RS18280 3745576..3745995 + 420 WP_045623284.1 helix-turn-helix domain-containing protein Antitoxin
D8768_RS18285 3746263..3746709 - 447 WP_045623318.1 hypothetical protein -
D8768_RS18290 3747240..3747617 - 378 WP_108367280.1 hypothetical protein -
D8768_RS18295 3747831..3748313 - 483 WP_063139119.1 immunity 26/phosphotriesterase HocA family protein -
D8768_RS18300 3748310..3749368 - 1059 WP_157508253.1 RHS domain-containing protein -
D8768_RS18305 3750170..3750511 - 342 WP_127341381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.32 Da        Isoelectric Point: 9.8331

>T113155 WP_045623285.1 NZ_CP033102:3745268-3745579 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGYLRVMLFTDFERGKL
FIKHTSTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T113155 NZ_CP033102:3745268-3745579 [Enterobacter hormaechei]
ATGCCCGCAGTCTCAAGAGCGCCTTTCGACGCGGCCACCAGACATTTTCCTATTCAAGAACTCGCTCTGGAAGATCTTTA
CTGGGTACTAAAAGGAGAGCACTACCCATCACCAGACGACATGCGAAAGCGCTTCCCCAGCCGGGAGAGGATGAAATACC
GGGAAAAATGGTGGGTCATTGACGTAGGTGGCGGGTATTTAAGAGTAATGTTATTTACTGATTTTGAGCGCGGAAAGCTC
TTCATCAAACACACCAGCACTCACGCAGATTATGACAAGCTCACGGACCTCTACCGGAGAAAGAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15522.56 Da        Isoelectric Point: 4.7722

>AT113155 WP_045623284.1 NZ_CP033102:3745576-3745995 [Enterobacter hormaechei]
MNFSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVQVSAFVGN

Download         Length: 420 bp

>AT113155 NZ_CP033102:3745576-3745995 [Enterobacter hormaechei]
ATGAACTTTTCAGCAGCCATCAAAGCGGCAAACGATCTAACAAGGGAGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTATGAGGATGCTATGGGGTTGGTGGAGTATCTAATTGAGCATGACCCCGATAGTCCGCTGGTAGAGATGCTCACCG
CTAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACGCGCGTGTTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAGTACCATCTCACTCAGAGCGATTTCGAAAACGAAATAGGTAAGAAGTCTCTGGT
GAGTCGGATCCTCAACGGACAGCGCACGTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGCGTGCAGGTAA
GTGCATTTGTGGGGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References