Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 53848..54367 Replicon chromosome
Accession NZ_CP033098
Organism Staphylococcus warneri strain SWO

Toxin (Protein)


Gene name yoeB Uniprot ID A0A364USX6
Locus tag EAH52_RS00225 Protein ID WP_002466416.1
Coordinates 54095..54367 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2T4PYE3
Locus tag EAH52_RS00220 Protein ID WP_002466398.1
Coordinates 53848..54102 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAH52_RS00205 49365..50687 + 1323 WP_122135046.1 PrsW family intramembrane metalloprotease -
EAH52_RS00210 50838..51275 + 438 WP_002466379.1 hypothetical protein -
EAH52_RS00215 51402..53603 - 2202 WP_002466389.1 YSIRK-type signal peptide-containing protein -
EAH52_RS00220 53848..54102 + 255 WP_002466398.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EAH52_RS00225 54095..54367 + 273 WP_002466416.1 Txe/YoeB family addiction module toxin Toxin
EAH52_RS00230 54760..56130 + 1371 WP_002450206.1 citrate:proton symporter -
EAH52_RS00235 56223..56861 - 639 WP_002466369.1 NAD(P)H-dependent oxidoreductase -
EAH52_RS00240 57148..58578 + 1431 WP_002466385.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10852.63 Da        Isoelectric Point: 9.9029

>T113132 WP_002466416.1 NZ_CP033098:54095-54367 [Staphylococcus warneri]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINQLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYHYFK

Download         Length: 273 bp

>T113132 NZ_CP033098:54095-54367 [Staphylococcus warneri]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCAATTGATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9345.27 Da        Isoelectric Point: 4.0334

>AT113132 WP_002466398.1 NZ_CP033098:53848-54102 [Staphylococcus warneri]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ESYE

Download         Length: 255 bp

>AT113132 NZ_CP033098:53848-54102 [Staphylococcus warneri]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTACTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364USX6

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PYE3

References